(R)-5,7-difluorochroman-4-ol
- CAS No.
- 1270294-05-7
- Chemical Name:
- (R)-5,7-difluorochroman-4-ol
- Synonyms
- (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol;Tegoprazan Impurity 11;R-5,7-difluorobenzo dihydropyran-4-ol;Tegoprazan Impurity;Tegoprazan side chain;Tegoprazan ImpuritiesC;Tigora produced impurity 11;(R)-5, 7-difluorobenzopyrane-4-ol;2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-;[2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine]
- CBNumber:
- CB23354564
- Molecular Formula:
- C9H8F2O2
- Molecular Weight:
- 186.16
- MOL File:
- 1270294-05-7.mol
- Modify Date:
- 2024/4/15 18:41:30
| Boiling point | 228.4±40.0 °C(Predicted) |
|---|---|
| Density | 1.402±0.06 g/cm3(Predicted) |
| pka | 13.09±0.20(Predicted) |
| InChI | InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1 |
| InChIKey | HGTYMLFMXKYIQW-SSDOTTSWSA-N |
| SMILES | C1OC2=CC(F)=CC(F)=C2[C@H](O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(R)-5,7-difluorochroman-4-ol Chemical Properties,Uses,Production
Uses
(R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].
Production Methods
Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].
References
[1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.
(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-5,7-difluorochroman-4-ol Suppliers
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