NONACTIN
- CAS No.
- 6833-84-7
- Chemical Name:
- NONACTIN
- Synonyms
- 3584-a;a-5584;e-79-c;n-329-a;NONACTIN;ta-25-m-i;fh-3582-a;POLYNACTIN;WERRAMYCIN A;AMMONIUM IONOPHORE
- CBNumber:
- CB2424675
- Molecular Formula:
- C40H64O12
- Molecular Weight:
- 736.93
- MOL File:
- 6833-84-7.mol
- Modify Date:
- 2023/5/18 11:31:08
| Melting point | 147-148° |
|---|---|
| Boiling point | 890.6±65.0 °C(Predicted) |
| Density | 1.11-1.15 g/cm3 |
| storage temp. | 2-8°C |
| solubility | chloroform: soluble10mg/mL |
| form | White to off-white crystalline solid. |
| color | white to faint yellow |
| Sensitive | Moisture Sensitive |
| Merck | 13,6709 |
| BRN | 76434 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | RH1685000 |
| F | 10-21 |
| HS Code | 29321900 |
| Toxicity | LD50 intravenous in mouse: 246mg/kg |
NONACTIN price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N2286 | Nonactin from Streptomyces griseus, ≥98% (function tested, HPLC) | 6833-84-7 | 10MG | ₹12990 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N2286 | Nonactin from Streptomyces griseus, ≥98% (function tested, HPLC) | 6833-84-7 | 100MG | ₹61388.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 09877 | Ammonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC) | 6833-84-7 | 50MG | ₹34888.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 74155 | Nonactin from Streptomyces sp., ≥97.0% (TLC) | 6833-84-7 | 5MG | ₹8868.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 09877 | Ammonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC) | 6833-84-7 | 250MG | ₹162126.03 | 2022-06-14 | Buy |
NONACTIN Chemical Properties,Uses,Production
Chemical Properties
Light yellow powder
Uses
Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.
Biological Activity
Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
Purification Methods
This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]
NONACTIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48467 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9274 | 58 | Inquiry |
| Anhui kuer Bioengineering Co., Ltd | 0551-65171243 13810511747 | China | 2997 | 55 | Inquiry |
| Guangzhou Yaoguang Technology Co., Ltd. | 13020159086 | China | 490 | 58 | Inquiry |
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