NONACTIN
- ₹8868.9 - ₹162126.03
- Product name: NONACTIN
- CAS: 6833-84-7
- MF: C40H64O12
- MW: 736.93
- EINECS:229-911-3
- MDL Number:MFCD00043039
- Synonyms:ta-25-m-i ;NONACTIN;NONACTIN, STREPTOMYCES GRISEUS;POLYNACTIN;NONACTIN FROM STREPTOMYCES GRISEUS;NONACTINE, FROM STREPTOMYCES SP.;NONACTIN FROM STREPTOMYCES TSUSIMAENSIS;nonactinfromstreptomycessp.
5 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 50MG
- 100MG
- 250MG
- ManufacturerSigma-Aldrich(India)
- Product number74155
- Product descriptionNonactin from Streptomyces sp., ≥97.0% (TLC)
- Packaging5MG
- Price₹8868.9
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberN2286
- Product descriptionNonactin from Streptomyces griseus, ≥98% (function tested, HPLC)
- Packaging10MG
- Price₹12990
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number09877
- Product descriptionAmmonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC)
- Packaging50MG
- Price₹34888.98
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberN2286
- Product descriptionNonactin from Streptomyces griseus, ≥98% (function tested, HPLC)
- Packaging100MG
- Price₹61388.58
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number09877
- Product descriptionAmmonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC)
- Packaging250MG
- Price₹162126.03
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 74155 | Nonactin from Streptomyces sp., ≥97.0% (TLC) | 5MG | ₹8868.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | N2286 | Nonactin from Streptomyces griseus, ≥98% (function tested, HPLC) | 10MG | ₹12990 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 09877 | Ammonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC) | 50MG | ₹34888.98 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | N2286 | Nonactin from Streptomyces griseus, ≥98% (function tested, HPLC) | 100MG | ₹61388.58 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 09877 | Ammonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC) | 250MG | ₹162126.03 | 2022-06-14 | Buy |
Properties
Melting point :147-148°
Boiling point :890.6±65.0 °C(Predicted)
Density :1.11-1.15 g/cm3
storage temp. :2-8°C
solubility :chloroform: soluble10mg/mL
form :White to off-white crystalline solid.
color :white to faint yellow
Sensitive :Moisture Sensitive
Merck :13,6709
BRN :76434
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Boiling point :890.6±65.0 °C(Predicted)
Density :1.11-1.15 g/cm3
storage temp. :2-8°C
solubility :chloroform: soluble10mg/mL
form :White to off-white crystalline solid.
color :white to faint yellow
Sensitive :Moisture Sensitive
Merck :13,6709
BRN :76434
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety Information
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Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Nonactin is a cyclic ionophore and part of the macrotetrolide antibiotics family. The ionophore is commonly produced by several species of Streptomyces which selectively binds K+ and NH4+. Nonactin has been recorded to function by binding a metal ionophore and transporting it across cell membranes for release. The compound can functionally perform this transport due to its conformational flexibility and hydrophobic exterior. The compound forms a natural diastereomer which is required for its antibacterial and binding capacities.At a concentration of 1x10-7 M Nonactin uncoupled oxidative phosphorylation and induced ATP hydrolysis. The compound has been observed to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. In the presence of Thallus acetate, Nonactin has further stimulated the swelling of rat liver mitochondria than thallus acetate alone. It also has inhibited the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in MDR cancer cells. Nonactin has been shown to inhibit the production and gene transcription of IL-5 but not of IL-2 or IL-4. Nonactin has also been used as an ammonium ionophore for ammonium ion determination in a potentiometric electrode for biosensor construction as well as in a fluorescent immuno assay to detect K+ ions in pharmaceutical samples.
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