HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

CAS No.: 29400-42-8

Chemical Name:: HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

Synonyms: fumigacin;Helvolic acid (Fumigacin);HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS;6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-beta)--alph;17(20),24-trien-21-oicacid,6,16-bis(acetyloxy)-3,7-dioxo-29-nordammara-(4;(8α,9β,13α,14β,17Z)-6β,16β-Diacetoxy-3,7-dioxo-29-nor-5α-dammara-1,17(20),24-trien-21-oic acid;(8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid;(4α,8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid;29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4α,6β,8α,9β,13α,14β,16β,17Z)-

CBNumber:: CB2503570

Molecular Formula:: C33H44O8

Molecular Weight:: 568.7

MOL File:: 29400-42-8.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:04

Request For Quotation

HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Properties

Melting point	215°
alpha	D25 -121° (chloroform)
Boiling point	552.56°C (rough estimate)
Density	1.1062 (rough estimate)
refractive index	1.4900 (estimate)
storage temp.	2-8°C
solubility	DMF:30.0(Max Conc. mg/mL);52.75(Max Conc. mM) DMSO:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);35.17(Max Conc. mM)
form	A crystalline solid
pka	4.05±0.41(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

RTECS	RC1370000
HS Code	29419000

HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Chemical Properties,Uses,Production

Description

Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.

Uses

Helvolic acid is a mycotoxin with antibacterial activity.

Definition

ChEBI: A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.

HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Preparation Products And Raw materials

Raw materials

Preparation Products

HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Suppliers

Global( 27)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
TargetMol Chemicals Inc.	15002134094	China	28118	58	Inquiry
Guangzhou Yaoguang Technology Co., Ltd.	13020159086	China	487	58	Inquiry
Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo	18584079237	China	2508	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	China	9708	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
BOC Sciences	58
Aladdin Scientific	58
TargetMol Chemicals Inc.	58
Guangzhou Yaoguang Technology Co., Ltd.	58
Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo	58
Cayman Chemical Company	81
Shanghai EFE Biological Technology Co., Ltd.	58

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3-ACETOXY-2-BUTANONE 2,2-DIMETHYLCYCLOHEXANONE 5-Hydroxy-4-octanone ETHYLIDENECYCLOPENTANE HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS

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17(20),24-trien-21-oicacid,6,16-bis(acetyloxy)-3,7-dioxo-29-nordammara-(4 6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-beta)--alph fumigacin HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS (4α,8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid (8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid (8α,9β,13α,14β,17Z)-6β,16β-Diacetoxy-3,7-dioxo-29-nor-5α-dammara-1,17(20),24-trien-21-oic acid 29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4α,6β,8α,9β,13α,14β,16β,17Z)- Helvolic acid (Fumigacin) 29400-42-8 C33H44O8