lymecycline
- CAS No.
- 992-21-2
- Chemical Name:
- lymecycline
- Synonyms
- Tetralysal;Armyl;Tertamyl;Tetramyl;Mucomycin;Tetralisal;Lymecycline;Limeciclina;Vebicyclysal;Lymecycline (85%)
- CBNumber:
- CB2891297
- Molecular Formula:
- C29H38N4O10
- Molecular Weight:
- 602.63
- MOL File:
- 992-21-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/27 11:17:45
| Melting point | 192.5°C |
|---|---|
| Boiling point | 648.97°C (rough estimate) |
| Density | 1.53 |
| refractive index | 1.5500 (estimate) |
| storage temp. | Amber Vial, -86°C Freezer, Under inert atmosphere |
| solubility | Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| form | Solid |
| pka | 2.50±0.24(Predicted) |
| color | Yellow to Dark Brown |
| Stability | Light Sensitive, Temperature Sensitive |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H332-H302-H334 |
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
lymecycline Chemical Properties,Uses,Production
Chemical Properties
Yellow, hygroscopic powder.
Uses
Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
Definition
ChEBI: A tetracycline-based broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall.
Pharmaceutical Applications
2-N-lysinomethyl-tetracycline. A water-soluble prodrug of
tetracycline available for oral administration.
Its antimicrobial activity is due to the tetracycline content. It
is lipophilic, rapidly absorbed from the gastrointestinal tract and
widely distributed. Concentrations around 1 mg/kg have been
found in maxillary sinus tissue some 3 h after administration
of a conventional dose. The half-life is 7–14 h. Approximately
30% of an orally administered dose is excreted as active drug in
the urine, where it achieves concentrations of 300 mg/L.
Its untoward effects and clinical uses are those of tetracycline,
although it is claimed to be better tolerated.
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: possibly enhanced anticoagulant
effect of coumarins and phenindione.
Oestrogens: possibly reduce contraceptive effects of
oestrogens (risk probably small).
Retinoids: possible increased risk of benign
intracranial hypertension – avoid.
Metabolism
The tetracyclines are excreted in the urine and in the faeces. Renal clearance is by glomerular filtration. Up to 60% of an intravenous dose, and up to 55% of an oral dose, is eliminated unchanged in the urine. Usually between 40% and 70% of a dose is excreted in the urine; urinary excretion is increased if urine is alkalinised.
lymecycline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vadivarhe Speciality Chemicals Limited | +91-9028832204 +91-9028832204 | Maharashtra, India | 38 | 58 | Inquiry |
| Kopran Ltd | +91-9920289074 +91-9820220525 | Maharashtra, India | 21 | 58 | Inquiry |
| SVR Drugs Pvt Ltd | +91-9849004148 +91-9010204960 | Hyderabad, India | 29 | 58 | Inquiry |
| REXIN Laboratories (Redson Group) | +91-9898937773 +91-8866003844 | Gujarat, India | 11 | 58 | Inquiry |
| Enaltec Labs Pvt Ltd | +91-9167119247 +91-9167119247 | Maharashtra, India | 49 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10311 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |