adamexine
- CAS No.
- 54785-02-3
- Chemical Name:
- adamexine
- Synonyms
- adamexine;N-[2-[[1-adamantyl(methyl)amino]methyl]-4,6-dibromophenyl]acetamide;N-[2-[[1-adamantyl(methyl)amino]methyl]-4,6-dibromo-phenyl]acetamide;N-[2-[[1-adamantyl(methyl)amino]methyl]-4,6-dibromo-phenyl]ethanamide
- CBNumber:
- CB2891565
- Molecular Formula:
- C20H26Br2N2O
- Molecular Weight:
- 470.246
- MOL File:
- 54785-02-3.mol
- Modify Date:
- 2023/5/4 17:34:39
adamexine Chemical Properties,Uses,Production
Originator
Adamexine ,ZYF Pharm Chemical
Manufacturing Process
4.3 g 2-brommemtyl-4,6-dibromo-N,N-diacetylaniline and 1.65 g Nmethyladamantyl amine in 100 ml of absolute ethanol were heated to reflux for 8 hours. The ethanol was removed and a residue was washed with some times with ether. The resulting hard mass was refluxed with 150 ml 2 N HCl for 2 hours. The obtained product was cooled and stood for 10-12 hours at 4°C in a refrigerator. The crystalline 2-(N-(1-adamantyl)-Nmethylaminomethyl- 4',6'-dibromacetanilid hydrochloride (adamexine) was filtered off and thoroughly washed with distilled water. It was recrystallized from a mixture glacial acetic acid/water 2:1 (v/v) to give a white crystalline powder, melting at 250°-254°C. The hydrochloride is better for a pharmaceutical composition because of solubility in water. The free base may be prepared by adding of an equivalent of any basic compound (NaOH, NaHCO3 and so on).
Therapeutic Function
Mucolytic
adamexine Preparation Products And Raw materials
Raw materials
Preparation Products
adamexine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | United States | 38470 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |