ISOPROPAMIDE IODIDE
- CAS No.
- 71-81-8
- Chemical Name:
- ISOPROPAMIDE IODIDE
- Synonyms
- r79;isamid;darbid;5579md;skf4740;dipramid;priamide;sanulcin;Tyrimide;dipramide
- CBNumber:
- CB3123931
- Molecular Formula:
- C23H33IN2O
- Molecular Weight:
- 480.43
- MOL File:
- 71-81-8.mol
- Modify Date:
- 2024/8/4 20:11:12
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | BP0693200 | |||||||||
| HS Code | 2924296000 | |||||||||
| Toxicity | LD50 oral in rat: > 10gm/kg | |||||||||
| NFPA 704 |
|
ISOPROPAMIDE IODIDE price More Price(2)
ISOPROPAMIDE IODIDE Chemical Properties,Uses,Production
Uses
Isopropamide Iodide acts as an anticholinergic compound with inhibitory activity. Also acts as a muscarinic receptor antagonist which can be applied to treatment of diseases affecting cognition including Alzheimer’s disease.
Uses
Isopropamide inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used for treating stomach ulcers and inflamed intestine.
General Description
Isopropamide iodide, 3-carbamoyl-3,3-diphenylpropyl)diisopropylmethylammoniumiodide (Darbid), occurs as a bitter, white to pale yellow, crystallinepowder that is only sparingly soluble in water butfreely soluble in chloroform and alcohol.
This drug, introduced in 1957, is a potent anticholinergic,producing atropine-like effects peripherally. Even with itsquaternary nature, it does not cause sympathetic blockade atthe ganglionic level except at high dosages. Its principal distinguishingfeature is its long duration of action. A singledose can provide antispasmodic and antisecretory effects foras long as 12 hours.
Clinical Use
ISOPROPAMIDE IODIDE is used as adjunctive therapy in the treatment of pepticulcer and other conditions of the GI tract associated withhypermotility and hyperacidity. It has the usual side effectsof anticholinergics (dryness of mouth, mydriasis, difficulturination) and is contraindicated in glaucoma, prostatic hypertrophy,etc.
Synthesis
Isopropamide, (3-carbamoyl-3,3-diphenylpropyl)di-iso-propylmethyl ammonium iodide (14.1.25), is synthesized by alkylating diphenylacetonitrile with di-isopropylaminoethylchloride in the presence of sodium amide, and the subsequent hydrolysis of the nitrile group of the resulting compound (14.1.23) to an amide group (14.1.24). Alkylation of this compound with methyliodide gives isopropamide (14.1.25) [19¨C22].
ISOPROPAMIDE IODIDE Preparation Products And Raw materials
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|---|---|---|---|---|---|
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