isatidine
- CAS No.
- 15503-86-3
- Chemical Name:
- isatidine
- Synonyms
- isatidine;Retrorsin-N-oxid;RETRORSINE-N-OXIDE;12,18-Dihydroxysenecionane-11,16-dione 4-oxide;12,18-Dihydroxy-11,16-dioxosenecionane 4-oxide;[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, 12-oxide, (3Z,5R,6S,14aR,14bR)-
- CBNumber:
- CB31306005
- Molecular Formula:
- C18H25NO7
- Molecular Weight:
- 367.39
- MOL File:
- 15503-86-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/15 10:43:14
| Melting point | 145°C |
|---|---|
| Boiling point | 497.95°C (rough estimate) |
| Density | 1.3204 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| pka | 11.96±0.40(Predicted) |
| IARC | 3 (Vol. 10, Sup 7) 1987 |
| EPA Substance Registry System | Isatidine (15503-86-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H373-H300 |
| Precautionary statements | P260-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
| RIDADR | 1544 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
isatidine Chemical Properties,Uses,Production
Description
This hepatotoxic alkaloid occurs in certain Senecio species and was first isolated from S. isatideus D.C. It occurs abundantly in S. retrorsus D.C. and S. scleratus Schw. The alkaloid crystallizes in rhombic prisms as the dihydrate and has [α]27D . 8.25° (H 20). It is soluble in MeOH, hot EtOH and hot H20 but virtually insoluble in Et 20, Me2CO or CHCl 3. On reduction it absorbs 4 molecules of H2 to give hexahydrodeoxyisatidine which melts at l15-l20°C and then remelts at l83-4°C following an intermediate solidification. This compound gives a hydrochloride, m.p. 218°C (dec.); [α]20D - 52.5° (H20) and may be hydrolyzed with Ba(OHh to give a basic product, tetrahydroisatinecine, CSH1703N, m.p. l74.5°C; [α]20D - 88° (H 20). The alkaloid itself, on hydrolysis with Ba(OHh yields isatinecine and two acid products, isatinecic acid and the monolactone, the latter almost certainly being formed by the action of the base upon the acid.
Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. See also ESTERS.
References
Blackie., Pharrn. J., 138, 102 (1937) de Waal., Onderstepoort J., 12, 155 (1939) de Waal., Nature, 146, 777 (1940) de Waal., Pretorius., OnderstepoortJ., 17,181 (1941) Leisegang, Warren., J. Chern. Soc., 702 (1950)
isatidine Preparation Products And Raw materials
Raw materials
Preparation Products
isatidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | China | 9247 | 58 | Inquiry |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 18108052721 | China | 5182 | 58 | Inquiry |
| Shanghai Moqi Biological Technology Co., LTD | 021-38218169 13341702378 | China | 9117 | 58 | Inquiry |
| Naturewill Biotechnology Co., Ltd. | 18113192475 18113192475 | China | 5000 | 58 | Inquiry |
| Nanjing Digger Medical Technology Co. Ltd. | 025-025-51191215 18013836722 | China | 4933 | 58 | Inquiry |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 | China | 9614 | 58 | Inquiry |
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