Follicle stimulating hormone
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: 50 mg/mL, soluble |
| form | white powder |
| color | White to off-white |
| Merck | 13,4249 |
| EPA Substance Registry System | Gonadotropin, menopausal(9002-68-0) |
Follicle stimulating hormone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F4021 | Follicle Stimulating Hormone from human pituitary ~7,000?IU/mg (vs. W.H.O. reference preparation 83/575) | 9002-68-0 | 2μG | ₹8064.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F4021 | Follicle Stimulating Hormone from human pituitary ~7,000?IU/mg (vs. W.H.O. reference preparation 83/575) | 9002-68-0 | 10μG | ₹23176.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F4021 | Follicle Stimulating Hormone from human pituitary ~7,000?IU/mg (vs. W.H.O. reference preparation 83/575) | 9002-68-0 | 25μG | ₹59429.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F4021 | Follicle Stimulating Hormone from human pituitary ~7,000?IU/mg (vs. W.H.O. reference preparation 83/575) | 9002-68-0 | 0.1MG | ₹199396.5 | 2022-06-14 | Buy |
Follicle stimulating hormone Chemical Properties,Uses,Production
Description
Gonal-F was launched in Austria, Germany, Denmark, Ireland, Italy, Norway, Sweden, Switzerland, France and the UK for the treatment of infertility. The recombinant follicule stimulating hormone (recFSH) was produced by introducing the genes for the α- and β-FSH subunits into the genome of Chinese hamster ovary cells. The isolated recFSH was a glycosylated bioactive dimer that appeared to be identical to urinary human FSH. Biochemically, the recFSH was equal to or slightly better to the uroFSH. The ultra-high purity of recFSH makes it less prone to side effects from contaminants in uroFSH and can be injectable.
Chemical Properties
Solid; soluble in water.
Uses
Follicle stimulating hormone (FSH) from human pituitary has been used for-
- in vitro luteinization of Macaque granulosa cells
- luteal cell proliferation assay
- culturing of preantral follicle cells obtained from mice
- in vitro maturation of immature cumulus-oocyte complexes (COCs) obtained from mice and
- culture of RAW264.7 cell line
Definition
A gonadotropic glycoprotein secreted by the anterior pituitary gland. It regulates the metabolic activity of the granulosa of the mammalian ovary; stimulates maturation of ovarian follicles, and production of estrogens. Spermatogenesis is partially under
Biological Functions
Follitropins are hormonal products that consist entirely of FSH and are used to stimulate ovarian follicle growth in women who do not have primary ovarian failure. In the absence of an adequate endogenous LH surge, however, hCG must be given following the use of follitropins to stimulate ovulation.
General Description
The α chain of FSH?has 89 amino acids and the β chain has 115 amino acids. The α chain is not active. FSH belongs to glycoprotein hormone family. It is secreted by the gonadotropic cells of pituitary gland.
Clinical Use
The gonadotropin follicle-stimulating hormones (FSH), follitropin alfa (Gonal-F) and follitropin beta (Follistim), are produced in the anterior lobe of the pituitary gland. FSH can function in two ways. On the one hand, it causes increased spermatogenesis in men. On the other hand, in concert with estrogen and luteinizing hormone (LH), it stimulates follicular growth and development in women. Consequently, FSH may be useful in the treatment of infertility. FSH is a member of a superfamily of proteins, all structurally related, which includes LH, chorionic gonadotropin, and thyroid-stimulating hormone (TSH).
Purification Methods
FSH is purified by Sephadex G100 gel filtration followed by carboxymethyl-cellulose with NH4OAc pH 5.5. The latter separates luteinising hormone from FSH. Its solubility in H2O is 0.5%. It has an isoelectric point of 4.5. A solution of 1mg in saline (100mL) can be kept at 60o for 0.5hour. Activity is retained in a solution at pH 7-8 for 0.5hour at 75o. The activity of a 50% aqueous EtOH solution is destroyed at 60o in 15minutes. [Bloomfield et al. Biochim Biophys Acta 533 371 1978, Hartree Biochem J 100 754 1966, Pierce & Parsons Ann Rev Biochem 50 465 1981.]
Follicle stimulating hormone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Rxn Chemicals Pvt Ltd | +91 (80) 5535-9566 | New Delhi, India | 88 | 0 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21671 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Nanjing Economic Development Co., Ltd | +86-25-52851511 | China | 189 | 56 | Inquiry |
| Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | China | 10787 | 58 | Inquiry |
| HUBEI HICKS BIOCHEMICAL CO.,LTD | 18696113233 | China | 1616 | 58 | Inquiry |