nimotuzumab
- CAS No.
- 828933-51-3
- Chemical Name:
- nimotuzumab
- Synonyms
- nimotuzumab;Research Grade Nimotuzumab(DHB86914)
- CBNumber:
- CB42498825
- Molecular Formula:
- Molecular Weight:
- 0
- MOL File:
- Mol file
nimotuzumab Chemical Properties,Uses,Production
Description
Overexpression of epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase, is prevalent in malignant tumors of epithelial origin and is especially common in breast, head and neck, colon, and lung cancer. With EGFR overexpression, prognosis is poor due to associated tumor invasion, metastasis, enhanced angiogenesis, and resistance to chemotherapy; thus, modulation of EGFR-mediated signaling is an attractive target for intervention. Small-molecule kinase inhibitors (gefitinib and erlotinib) and a monoclonal antibody (cetuximab) specific for EGFR are in clinical evaluation, but treatment cessation due to development of severe acne-like rash is common with these EGFR antagonists. Notably, nimotuzumab, a humanized form of the murine IgG2a monoclonal antibody that has been launched in India for treatment of head and neck cancers overexpressing EGFR, demonstrates clinical efficacy devoid of the rash toxicity. .
Originator
Center for Molecular Immunology (Cuba)
brand name
BioMab EFGR, Theraloc
nimotuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9707 | 58 | Inquiry |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 13720134139 | China | 5404 | 58 | Inquiry |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | China | 10351 | 58 | Inquiry |
| Changsha Fuzhen Biotechnology Co.，LTD | 0731-18670069 18670069958 | China | 3195 | 58 | Inquiry |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | China | 1565 | 58 | Inquiry |
| AntibodySystem | 18162686757 18162686757 | China | 9818 | 58 | Inquiry |
| Olix (Shanghai) Pharmaceutical Technology Co., Ltd | 17316404525 | China | 9716 | 58 | Inquiry |
| Jiangxi ravel Biotechnology Co.,Ltd | 13184580281 | China | 2713 | 58 | Inquiry |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | China | 7969 | 58 | Inquiry |