니모투주맙

니모투주맙 C화학적 특성, 용도, 생산

개요

Overexpression of epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase, is prevalent in malignant tumors of epithelial origin and is especially common in breast, head and neck, colon, and lung cancer. With EGFR overexpression, prognosis is poor due to associated tumor invasion, metastasis, enhanced angiogenesis, and resistance to chemotherapy; thus, modulation of EGFR-mediated signaling is an attractive target for intervention. Small-molecule kinase inhibitors (gefitinib and erlotinib) and a monoclonal antibody (cetuximab) specific for EGFR are in clinical evaluation, but treatment cessation due to development of severe acne-like rash is common with these EGFR antagonists. Notably, nimotuzumab, a humanized form of the murine IgG2a monoclonal antibody that has been launched in India for treatment of head and neck cancers overexpressing EGFR, demonstrates clinical efficacy devoid of the rash toxicity. .

Originator

Center for Molecular Immunology (Cuba)

상표명

BioMab EFGR, Theraloc

니모투주맙 준비 용품 및 원자재

원자재

준비 용품

니모투주맙 공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
NCE Biomedical Co.,Ltd.	4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988		China	1494	55
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8013	62
Guangzhou Hongyuan Chemical Co.,Ltd	15817493340	981810490@qq.com	China	1566	58
Wuhan Chemstan Biotechnology Co., Ltd.	027-65317797 15926423062	422450190@qq.com	China	10022	58
Abmole Bioscience Inc.	021-50967598 02150967598	sales@abmole.cn	China	4495	58
Jiangxi ravel Biotechnology Co.,Ltd	13184580281	hj@ruiweier.cn	China	2711	58

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