벨리무맙

벨리무맙 C화학적 특성, 용도, 생산

개요

Belimumab was approved by the U.S. FDA in March 2011 for treatment of patients with active, autoantibody-positive, systemic lupus erythematosus (SLE). Belimumab is a human sequence monoclonal antibody that binds to human B lymphocyte stimulator protein (BLys; also known as BAFF, THANK, TALL-1, TNFSF13B, and zTNF4), which is overexpressed in SLE patients. BLys is expressed on the cell surface of monocytes, macrophages, and monocyte-derived dendritic cells and is cleaved to form a soluble cytokine that stimulates cell proliferation and antibody secretion in B lineage cells that express the BLys receptor BAFF-R (also known as BR-3). The precise function of two additional BLys receptors, TACI and BCMA, is less clear. Belimumab inhibits BLys interaction with these three receptors leading to measurable reductions in autoantibodies, such as anti-dsDNA, and specific circulating B cell lineage compartments including antibody producing plasma cells. Belimumab was discovered by screening molecules from a phage display library of human single-chain Fv sequences for BLys binding and functional blocking, followed by optimization of the lead through the introduction of variant residues in V_H CDR3.

용도

Treatment of autoimmune disease.

벨리무맙 준비 용품 및 원자재

원자재

준비 용품

벨리무맙 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21670	55
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8013	62
Chemleader Biomedical Co., Limited.	021-58180488	sales@MedChemLeader.com	China	1007	58
Guangzhou Hongyuan Chemical Co.,Ltd	15817493340	981810490@qq.com	China	1566	58
Wuhan Chemstan Biotechnology Co., Ltd.	027-65317797 15926423062	422450190@qq.com	China	10022	58
Shaanxi Dideu Medichem Co. Ltd	029-81124267 15229202216	1073@dideu.com	China	10011	58
Hubei Kele Fine Chemical Co., Ltd	027-59101668 19945030958	2881924765@qq.com	China	7984	58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.	+86-027-59232304 15387063101	2881924050@qq.com	China	9934	58

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