Aflibercept

Aflibercept C화학적 특성, 용도, 생산

개요

In November 2011, the U.S. FDA approved the recombinant fusion protein aflibercept, administered as an intravitreal injection, for the treatment of patients with neovascular (wet) age-related macular degeneration (AMD). Aflibercept differs from these agents in that it acts as a soluble decoy receptor that binds all VEGF isoforms more tightly than their native receptors, thereby diverting VEGF from its normal function. Aflibercept consists of a fusion of the second Ig domain of human VEGF receptor 1 and the third Ig domain of human VEGF receptor 2 fused to the constant region of (Fc) of human immunoglobulin G1. Aflibercept is a dimeric glycoprotein with a protein molecular weight of 97 kDa and glycoside molecular weight of 18 kDa. It is produced in recombinant Chinese hamster ovary (CHO) cells that overexpress the fusion protein. Aflibercept has subpicomolar affinity for VEGF-A (K_D=0.66 pM for VEGF-A₁₆₅ and 0.19 pM for VEGF-A₁₂₁), the major driver of pathological angiogenesis and vascular leak in wet AMD.19 Ranibizumab and bevacizumab bind VEGF-A₁₆₅ with lower affinity (K_D=20.6 and 35.1 pM, respectively).

Originator

Regeneron Pharmaceuticals (United States)

상표명

Eylea

Aflibercept 준비 용품 및 원자재

원자재

준비 용품

Aflibercept 공급 업체

공급자	전화	이메일	국가	제품 수	이점
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15352	58
Chembest Research Laboratories Limited	+86-21-20908456	sales@BioChemBest.com	China	6005	61
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2123	70
LUCKY PHARMA CO., LIMITED	0571-86403260 86403970	lucky@lkbiology.com	China	243	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4566	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2988	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58
Wuhan Chemstan Biotechnology Co., Ltd.	027-65317797 15926423062	422450190@qq.com	China	10424	58
Abmole Bioscience Inc.	021-50967598 02150967598	sales@abmole.cn	China	4494	58

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