belimumab
- CAS No.
- 356547-88-1
- Chemical Name:
- belimumab
- Synonyms
- belimumab;LymphoStat B;Research Grade Belimumab;Belimumab (anti-TNFSF13B);Anti-Human BAFF(Belimumab);Research Grade Belimumab(DHJ85301)
- CBNumber:
- CB31856030
- Molecular Formula:
- Molecular Weight:
- 0
- MOL File:
- Mol file
- Modify Date:
- 2024/11/19 23:02:33
belimumab Chemical Properties,Uses,Production
Description
Belimumab was approved by the U.S. FDA in March 2011 for treatment of patients with active, autoantibody-positive, systemic lupus erythematosus (SLE). Belimumab is a human sequence monoclonal antibody that binds to human B lymphocyte stimulator protein (BLys; also known as BAFF, THANK, TALL-1, TNFSF13B, and zTNF4), which is overexpressed in SLE patients. BLys is expressed on the cell surface of monocytes, macrophages, and monocyte-derived dendritic cells and is cleaved to form a soluble cytokine that stimulates cell proliferation and antibody secretion in B lineage cells that express the BLys receptor BAFF-R (also known as BR-3). The precise function of two additional BLys receptors, TACI and BCMA, is less clear. Belimumab inhibits BLys interaction with these three receptors leading to measurable reductions in autoantibodies, such as anti-dsDNA, and specific circulating B cell lineage compartments including antibody producing plasma cells. Belimumab was discovered by screening molecules from a phage display library of human single-chain Fv sequences for BLys binding and functional blocking, followed by optimization of the lead through the introduction of variant residues in VH CDR3.
Uses
Treatment of autoimmune disease.
belimumab Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21628 | 55 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32159 | 58 | Inquiry |
| Aladdin Scientific | United States | 57505 | 58 | Inquiry | |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 400-6206333 13167063860 | China | 48458 | 58 | Inquiry |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | China | 1566 | 58 | Inquiry |
| Biolab Reagents | 027-65279366 18108604356 | China | 9868 | 58 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9803 | 58 | Inquiry |
| Wanxin Biotechnology (Jiaxing) Co., LTD | 0573-83568680 18057391398 | China | 1442 | 58 | Inquiry |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | China | 10356 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | 029-029-81124267 15229202216 | China | 10005 | 58 | Inquiry |