Ulipristal Acetate
- CAS No.
- 126784-99-4
- Chemical Name:
- Ulipristal Acetate
- Synonyms
- Ulipristal;17α-Acetoxy-11β-(4-dimethylaminophenyl)-19-norpregna-4,9-dien-3,20-dione;Uliprisnil Acetate;Esmya;EllaOne;CDB2914;VA 2914;RU 44675;CBD 2914;HRP 2000
- CBNumber:
- CB31400406
- Molecular Formula:
- C30H37NO4
- Molecular Weight:
- 475.62
- MOL File:
- 126784-99-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/6 17:55:34
Ulipristal Acetate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1469 | Ulipristal acetate ≥98% (HPLC) | 126784-99-4 | 10MG | ₹11290.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1469 | Ulipristal acetate ≥98% (HPLC) | 126784-99-4 | 50MG | ₹45778.93 | 2022-06-14 | Buy |
| TCI Chemicals (India) | U0102 | Ulipristal Acetate | 126784-99-4 | 50MG | ₹6400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | U0102 | Ulipristal Acetate | 126784-99-4 | 250MG | ₹14200 | 2022-05-26 | Buy |
Ulipristal Acetate Chemical Properties,Uses,Production
Description
Ulipristal acetate is a synthetic steroid derived from 19-nor-progesterone that exerts potent progesterone receptor (PR) antagonist activity at
the transcriptional level. It is an orally administered drug indicated for
emergency contraception (i.e., postcoital contraception) up to 120 h following unprotected intercourse. Ulipristal acetate is the second oral progestogen marketed for this indication behind levonorgestrel. As PR
antagonists, both drugs are believed to act via delay of ovulation and
inhibition of follicular development. Levonorgestrel 1.5 mg is approved
for contraception up to 72 h following unprotected intercourse and is
widely accessible via prescription, and directly from clinics and community pharmacies. Prior to ulipristal acetate, the only approved postcoital
contraceptive option between 72 and 120 h was the insertion of an intrauterine device (IUD). The recommended dose of ulipristal acetate is one
30-mg tablet taken as soon as possible and no more than 120 h following
intercourse. The vast majority of PR antagonists belonging to the mifepristone (RU486) family also bind to the glucocorticoid receptor (GR)
with high affinity and thereby exert antiglucocorticoid activity.
The most common adverse effects with ulipristal acetate were headache, dysmenorrhea, nausea, abdominal pain, dizziness, fatigue, and upper abdominal pain.
Chemical Properties
Pale Yellow Solid
Uses
Ulipristal acetate is a selective progesterone receptor modulator
Definition
ChEBI: A 20-oxo steroid obtained by acetylation of the 17-hydroxy group of (11beta,17alpha)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-ol (ulipristal). A selective progesterone receptor modulator, which is empl yed as an emergency contraceptive.
Clinical Use
Ulipristal acetate, a selective progesterone receptor modulator (SPRM), was developed at the Research Triangle Institute. In 2009, HRA Pharma received FDA approval for emergency contraception within 120 h (5 days) of unprotected sexual intercourse or contraceptive failure. Ulipristal acetate is a well-known steroid that possesses antiprogestational and antiglucocorticoid activity. It is the first SPRM that was specifically designed as an oral emergency contraceptive. Unlike earlier levonorgestrel-based emergency contraceptives, this SPRM drug maintains efficacy for 5 days after unprotected intercourse while having safety profile comparable to levonorgestrel.
Ulipristal Acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Swati Spentose Pvt Ltd | +91-2261505232 +91-2261505232 | Maharashtra, India | 44 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Sai Phytoceuticals Private Limited | 08048250470Ext 414 | Madhya Pradesh, India | 15 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 6011 | 58 | Inquiry |
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