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ChemicalBook > Product Catalog >Organic Chemistry >Heterocyclic Compounds >2-(2-bromo-4-fluorophenyl)pyrrolidine

2-(2-bromo-4-fluorophenyl)pyrrolidine

2-(2-bromo-4-fluorophenyl)pyrrolidine Structure
CAS No.
1016499-98-1
Chemical Name:
2-(2-bromo-4-fluorophenyl)pyrrolidine
Synonyms
2-(2-bromo-4-fluorophenyl)pyrrolidine;Pyrrolidine, 2-(2-bromo-4-fluorophenyl)-
CBNumber:
CB31556806
Molecular Formula:
C10H11BrFN
Molecular Weight:
244.1
MOL File:
1016499-98-1.mol
Modify Date:
2023/10/11 11:33:39
Request For Quotation

2-(2-bromo-4-fluorophenyl)pyrrolidine Chemical Properties,Uses,Production

Reactions

2-(2-bromo-4-fluorophenyl)pyrrolidine is an important intermediate for the synthesis of various organic compounds. This organic compound can be used to react with Pyrazolo(1,5a)pyrimidine to synthesize 4-fluoro-2-bromo-Larotrectinib, a radioactive iodine-marked Larotrectinib compound.
2-(2-bromo-4-fluorophenyl)pyrrolidine

Synthesis

The oily 5-(2-bromo-4-fluorobenzene)-3,4-dihydro-2H-pyrrole (6.05g, 0.025mmoL) was dissolved in 100mL of methanol and water (4:1) solution, cooled to 0 degree,Sodium borohydride (0.95 mg, 0.025 mmol) was added in portions with hydrogen evolution.The reaction solution became a yellow turbid liquid, and after 3 hours, it was allowed to warm to room temperature, and the solvent was distilled off.The residue was treated with KHCO3 and extracted with ethyl acetate.The organic layer was dried over anhydrous sodium sulfate and filtered and evaporated. A pale yellow oil was obtained, and 5.84 g of 2-(2-bromo-4-fluorophenyl)pyrrolidine crude product was obtained, with a yield of 95.7%, which was directly reacted.

2-(2-bromo-4-fluorophenyl)pyrrolidine Preparation Products And Raw materials

Raw materials

Methyl 2-bromo-4-fluorobenzoate

Preparation Products

2-(2-bromo-4-fluorophenyl)pyrrolidine Suppliers

Global( 9)Suppliers
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Tianjin Xinghan Biotechnology Co., Ltd +8618698089028 China 2479 58 Inquiry
Tianjin Xinghan Biotechnology Co., Ltd 13230698506 18698089028 China 5009 58 Inquiry
LABTER PHARMATECH(BEIJING) CO.,LTD 010-56330744 18310155299 China 23337 55 Inquiry
BioPharmaMatrix,Inc. 0510-86010668 China 4041 55 Inquiry
Hebei Boxin Biotechnology Co. , Ltd. 19131160546 China 13199 58 Inquiry
Shaoyuan Technology (Shanghai) Co., Ltd. 021-50795510 4000665055 China 8818 58 Inquiry
Beta Pharma, Inc. 203 786 5436 United States 6238 60 Inquiry
UkrOrgSynthesis Ltd. 380 445319497 Ukraine 6234 38 Inquiry
hengshui chirals technology Co.,Ltd 894232506 18830808696 China 3744 58 Inquiry
Supplier Advantage
Tianjin Xinghan Biotechnology Co., Ltd 58
Tianjin Xinghan Biotechnology Co., Ltd 58
LABTER PHARMATECH(BEIJING) CO.,LTD 55
BioPharmaMatrix,Inc. 55
Hebei Boxin Biotechnology Co. , Ltd. 58
Shaoyuan Technology (Shanghai) Co., Ltd. 58
Beta Pharma, Inc. 60
UkrOrgSynthesis Ltd. 38
hengshui chirals technology Co.,Ltd 58

1016499-98-1(2-(2-bromo-4-fluorophenyl)pyrrolidine)Related Search:

(S)-2-(4-Fluorophenyl)pyrrolidine 2-(2-Bromophenyl)pyrrolidine 2-(3,5-Dichlorophenyl)Pyrrolidine 2-(3-Chloro-phenyl)-pyrrolidine (R)-2-(2-Chlorophenyl)pyrrolidine
2-(2-bromo-4-fluorophenyl)pyrrolidine Pyrrolidine, 2-(2-bromo-4-fluorophenyl)- 1016499-98-1