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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >2-(3-Chloro-phenyl)-pyrrolidine

2-(3-Chloro-phenyl)-pyrrolidine

2-(3-Chloro-phenyl)-pyrrolidine Structure
CAS No.
298690-74-1
Chemical Name:
2-(3-Chloro-phenyl)-pyrrolidine
Synonyms
AKOS BB-8867;CHEMBRDG-BB 4006410;2-(3-CHLOROPHENYL)PYRROLIDINE;Pyrrolidine, 2-(3-chlorophenyl)-;(+/-)-2-(3-chlorophenyl)-pyrrolidine
CBNumber:
CB4175836
Molecular Formula:
C10H12ClN
Molecular Weight:
181.66
MOL File:
298690-74-1.mol
Modify Date:
2023/10/11 11:15:29
Request For Quotation

2-(3-Chloro-phenyl)-pyrrolidine Properties

Boiling point 138-141 °C(Press: 16 Torr)
Density 1.129±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka 9.58±0.10(Predicted)
CAS DataBase Reference 298690-74-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H314-H361-H410
Precautionary statements  P501-P273-P270-P202-P201-P264-P280-P391-P308+P313-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
HS Code  2933998090

2-(3-Chloro-phenyl)-pyrrolidine Chemical Properties,Uses,Production

Uses

Used as an intermediate for organic synthesis.

Application

(+/-)-2-(3-chlorophenyl)-pyrrolidine has a wide application in synthesis of pharma intermediates，It is also used as an antioxidant.

Reactions

2-(3-Chloro-phenyl)-pyrrolidine is an important building block for the synthesis of various organic compounds. Through the coupling of the amine, It could be employed to couple with 4-(4-formylphenoxy)-1-naphthamide to synthesize 4-[4-[2-(3-Chlorophenyl)pyrrolidin-1-yl]methylphenoxyl]-1-naphthamide which is an aminobenzyloxyarylamide derivatives and act as κ opioid receptor antagonists.

Synthesis

To a solution of substituted benzoic acid inabsolute ethyl alcohol was slowly added thionyl chloride. The mixture was heated to reflux for 2h, and then cooledto room temperature. The solvent was removed and the solid residuewas dissolved in ethyl acetate, and washed withsaturated NaHCO3 solution. After a series of reactions, 3-(2-chloro-phenyl)-pyrrolidine can be obtained.

2-(3-Chloro-phenyl)-pyrrolidine Preparation Products And Raw materials

Raw materials

3-Chlorobenzoic acid

Preparation Products

2-(3-Chloro-phenyl)-pyrrolidine Suppliers

Global( 75)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Tianjin Xinghan Biotechnology Co., Ltd +8618698089028 China 2479 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd +8613580539051 CHINA 21149 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49999 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Tianjin Xinghan Biotechnology Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
GIHI CHEMICALS CO.,LIMITED 58
Amadis Chemical Company Limited 58

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2-(3-CHLOROPHENYL)PYRROLIDINE AKOS BB-8867 CHEMBRDG-BB 4006410 Pyrrolidine, 2-(3-chlorophenyl)- (+/-)-2-(3-chlorophenyl)-pyrrolidine 298690-74-1