ChemicalBook > Product Catalog >Analytical Chemistry >Analysis reagents >General Analytical Reagents >(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
- CAS No.
- 20445-33-4
- Chemical Name:
- (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
- Synonyms
- (+)-MTPA-CL;R(-)-MTPA-CL;(S)-(+)-MTPA-CL;(2S)-2-Methoxy-2-;(+)-MOSHER'S CHLORIDE;(S)-(+)-MTPA-Chloride;(S)-(+)-Acid chloride;MOSHER'S ACID CHLORIDE;(+)-MOSHER'S ACID CHLORIDE;(S)-(+)-Mosher'sacidchloride
- CBNumber:
- CB3170768
- Molecular Formula:
- C10H8ClF3O2
- Molecular Weight:
- 252.62
- MOL File:
- 20445-33-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/28 17:44:41
| Boiling point | 213-214 °C(lit.) |
|---|---|
| alpha | D24 +129.0± 0.2° (c = 5.17 in CCl4) |
| Density | 1.35 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 194 °F |
| storage temp. | -20°C |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 1.353 |
| optical activity | [α]20/D +137±2°, c = 6.4% in carbon tetrachloride |
| Water Solubility | Slightly miscible with water. |
| Sensitive | Moisture Sensitive |
| Merck | 14,6280 |
| BRN | 3591564 |
| CAS DataBase Reference | 20445-33-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-43 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Corrosive/Freeze | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29189900 | |||||||||
| NFPA 704 |
|
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 65365 | (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride for chiral derivatization, LiChropur?, ≥99.0% | 20445-33-4 | 100MG | ₹11084.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 65365 | (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride for chiral derivatization, LiChropur?, ≥99.0% | 20445-33-4 | 500MG | ₹45042.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 369675 | (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride 99% | 20445-33-4 | 50MG | ₹2197.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 369675 | (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride 99% | 20445-33-4 | 250MG | ₹10565.2 | 2022-06-14 | Buy |
| ALFA India | ALF-L14332-MF | (S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+% | 20445-33-4 | 50mg | ₹2551 | 2022-05-26 | Buy |
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
Resolution of enantiomers primarily of alcohols and amines.
General Description
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.
Purification Methods
The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.]
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Suppliers
Global( 127)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | China | 8821 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | China | 5791 | 58 | Inquiry |
20445-33-4((S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE)Related Search:
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
1-Pentanol
Phenylacetyl chloride
3,3,3-TRIFLUOROPROPIONYL CHLORIDE
(R)-2-CHLORO-1-PHENYLETHANOL
3-CHLORO-1,1,1-TRIFLUOROPROPANE
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE,(+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
4-FLUORO-3-(TRIFLUOROMETHYL)ANISOLE
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(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%
(S)-(+)-MTPA-Cl, Moshers acid chloride
(S)-(+)-^a-Methoxy-^a-(trifluoromethyl)phenylacetyl chloride, 98+%
(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride,99%
(R)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(R)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE
R(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID CHLORIDE
(R)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(R)-(-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE
(R)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(+)-MOSHER'S ACID CHLORIDE
(S)-(+)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetyl chloride, 98+%
(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
(S)-(+)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride
(+)-MTPA-Cl
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride,(S)-(+)-MTPA-Cl, Mosher’s acid chloride
(2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99% (99%ee)
(S)-(+)-MTPACl, (S)-(+)-Mosher's acid chloride, (2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionyl chloride
(S)-(+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl chloride, 99% 1GR
(+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl Chloride (ca. 18% in DichloroMethane, ca. 1.0Mol/L) [for DeterMination of the optical purity of Alcohols and AMines]
(+)-Mosher's Acid Chloride
(+)-MTPA-Cl
(S)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoyl chloride
(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride [for DeterMination of the optical purity of Alcohols and AMines]
(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride (ca. 18% in DichloroMethane, ca. 1.0Mol/L) [for DeterMination of the optical purity of Alcohols and AMines]
(2S)-2-Methoxy-2-
Benzeneacetyl chloride, α-Methoxy-α-(trifluoroMethyl)-, (S)-
Hydratropoyl chloride, β,β,β-trifluoro-α-Methoxy-, (+)- (8CI)
(2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99%
(S)-3,3,3-Trifluoro-2-methoxy-2-phenylpropionyl chloride
S-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid chloride
MOSHER'S ACID CHLORIDE
(+)-MOSHER'S CHLORIDE
(+)-MTPA-CL
R(-)-MTPA-CL
(S)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE
(S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(S)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE
(S)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
(S)-(+)-MTPA-CL
(S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)-PH ENYLACETYL CHLORIDE, 99%(98% EE/GLC)
(R)-(+)-Methoxy-trifluoromethylphenylacetyl chloride
(S)-(+)-Mosher'sacidchloride
(S)-(+)-MTPA-Chloride
(S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetylchloride(ee)
(s)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetyl chloride
(S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 99%
(S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride (99%ee)
(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetylChloride[forDeterminationoftheopticalpurityofAlcoholsandAmines]
(s)-(+)-alphaMethoxy-alpha(three fluoroMethyl)phenyl acetyl chloride
(S)-2-Methoxy-2-(trifluoromethyl)phenylacetyl chloride
(2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoylchloride99%
(S)-(+)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride
(S)-(+)-Acid chloride
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride
(2S)-2-Methoxy-2-trifluoromethylphenylacetyl chloride
(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]