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ChemicalBook > Product Catalog >Organic Chemistry >Amides >Amino compound >Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Structure
CAS No.
473927-63-8
Chemical Name:
Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
Synonyms
Apixaban I;Apixaban int;Apixaban Impurity O;Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]acetate;Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate;Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl este...;Ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetate;ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate;Acetic acid, chloro[(4-Methoxyphenyl)hydrazono]-, ethyl ester, (2Z)-;(2Z)-2-Chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetic acid ethyl ester
CBNumber:
CB32514108
Molecular Formula:
C11H13ClN2O3
Molecular Weight:
256.69
MOL File:
473927-63-8.mol
MSDS File:
SDS
Modify Date:
2023/8/15 13:21:15
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Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Properties

Boiling point 349.0±44.0 °C(Predicted)
Density 1.23
vapor pressure 0.008Pa at 25℃
pka 11.63±0.10(Predicted)
InChI InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3/b14-10-
InChIKey ATNPZEGMKLGIFA-UVTDQMKNSA-N
SMILES C(OCC)(=O)/C(/Cl)=N/NC1=CC=C(OC)C=C1
LogP 2.53

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H311-H331-H341
Precautionary statements  P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Chemical Properties,Uses,Production

Uses

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical and pharmaceutical production processes.

Synthesis

Synthesis_473927-63-8
Preparation of ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate To p-anisidine (16 g, 0.129 mol) in conc. HCL (40 mL), 100 mL) H2O, cooled to -5?? C. and sodium nitrite (9.4 g, 0.136 mol) in H2O (60 mL) was added. The reaction mixture was stirred at -5?? C. for 20 min and a mixture of ethylchloroacetoacetate (22 g, 0.133 mol), ethanol (100 mL), sodiumacetate (32 g, 0.389 mmol), and H2O (400 mL) was added. The reaction was allowed to warm up to room temperature and stirred for 2h. The product precipitated as a black solid. It was filtered and dried (30 g). 1H-NMR (CDCl3) |? 8.28 (s, 1H), 7.18 (d, 2H), 6.90 (d, 2H), 4.41 (q, 2H), 3.80 (s, 3H), 1.42 (t, 3H) ppm.

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Preparation Products And Raw materials

Raw materials

Ethyl 2-chloroacetoacetate Sodium acetate p-Anisidine Ethyl chloroacetate

Preparation Products

Apixaban Impurity 17

Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate Suppliers

Global( 121)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Horizon +91-7517039862 +91-7517039862 Maharashtra, India 36 58 Inquiry
LAIRUS PHARMA PVTLTD +91-7517039862 +91-7517039862 Maharashtra, India 25 58 Inquiry
Nandana Laboratories Pvt. Ltd.(NLPL) +91-8978635484 +91-6281929762 Telangana, India 40 58 Inquiry
ARRKEM LIFE SCIENCES PRIVATE LIMITED +91-8148739767 +91-8148739767 Telangana, India 260 58 Inquiry
Arnavi Laboratory +91-7780703633 +91-7780703633 Telangana, India 83 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Jinan Million Pharmaceutical Co., Ltd +86-531-68659554 +8613031714605 China 159 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 16220 58 Inquiry
Speranza Chemical Co., Ltd. +86-86-075521030354 +8618688942810 China 723 55 Inquiry
Supplier Advantage
Horizon 58
LAIRUS PHARMA PVTLTD 58
Nandana Laboratories Pvt. Ltd.(NLPL) 58
ARRKEM LIFE SCIENCES PRIVATE LIMITED 58
Arnavi Laboratory 58
CLEARSYNTH LABS LTD. 58
Jinan Million Pharmaceutical Co., Ltd 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
Speranza Chemical Co., Ltd. 55

473927-63-8(Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate)Related Search:

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Acetic acid, chloro[(4-Methoxyphenyl)hydrazono]-, ethyl ester, (2Z)- Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate (2Z)-2-Chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetic acid ethyl ester Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]acetate Apixaban I ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate Apixaban Impurity O Apixaban int Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-, ethyl ester, (2Z)- Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl este... Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetateQ: What is Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Q: What is the CAS Number of Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetate 473927-63-8 473927-63-8