ChemicalBook > Product Catalog >Chemical pesticides >Pesticide Intermediates >Ethyl 2-chloroacetoacetate
Ethyl 2-chloroacetoacetate
- CAS No.
- 609-15-4
- Chemical Name:
- Ethyl 2-chloroacetoacetate
- Synonyms
- Ethyl 2-chloro-3-oxobutanoate;2-chloroacetoacetate;2-CHLORACETYLETHYL ACETATE;2-Chloro-3-oxobutanoic acid, ethyl ester;Butanoic acid, 2-chloro-3-oxo-, ethyl ester;A 21960;2-CL-ACE;AKOS BBS-00004302;Ethyl 2-chloroacetoa;2 - ethyl acetoacetate
- CBNumber:
- CB9396009
- Molecular Formula:
- C6H9ClO3
- Molecular Weight:
- 164.59
- MOL File:
- 609-15-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/27 8:57:20
| Melting point | -80 °C |
|---|---|
| Boiling point | 107 °C/14 mmHg (lit.) |
| Density | 1.19 g/mL at 25 °C (lit.) |
| vapor pressure | 49.4-100Pa at 20℃ |
| refractive index |
n |
| Flash point | 122 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Liquid |
| pka | 7.92±0.46(Predicted) |
| color | Clear yellow |
| Water Solubility | 17 g/L (20 ºC) |
| BRN | 774278 |
| LogP | 1.2 at 20℃ and pH1-7 |
| Surface tension | 69.4mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 609-15-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Butanoic acid, 2-chloro-3-oxo-, ethyl ester(609-15-4) |
| EPA Substance Registry System | Ethyl 2-chloroacetoacetate (609-15-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H335-H226-H302-H314 | |||||||||
| Precautionary statements | P210-P233-P240-P241+P242+P243-P260-P264-P270-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405-P501-P280-P305+P351+P338-P310-P261-P303+P361+P353-P501a | |||||||||
| Hazard Codes | C,Xn,F | |||||||||
| Risk Statements | 10-22-34-52/53-36/37/38-36 | |||||||||
| Safety Statements | 16-26-36/37/39-45-61-37/39 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 19 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29183000 | |||||||||
| NFPA 704 |
|
Ethyl 2-chloroacetoacetate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | C1218 | Ethyl 2-Chloroacetoacetate min. 95.0 %(total of isomer) | 609-15-4 | 25G | ₹1800 | 2022-05-26 | Buy |
| ALFA India | ALF-A19810-36 | Ethyl 2-chloroacetoacetate, 96% | 609-15-4 | 500g | ₹6897 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C1218 | Ethyl 2-Chloroacetoacetate min. 95.0 %(total of isomer) | 609-15-4 | 500G | ₹8500 | 2022-05-26 | Buy |
| ALFA India | ALF-A19810-22 | Ethyl 2-chloroacetoacetate, 96% | 609-15-4 | 100g | ₹2813 | 2022-05-26 | Buy |
Ethyl 2-chloroacetoacetate Chemical Properties,Uses,Production
Chemical Properties
clear bright yellow liquid
Uses
Ethyl 2-chloroacetoacetate was used to study reductive dechlorination of β-keto ester ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae.
Biochem/physiol Actions
Ethyl 2-chloroacetoacetate reacts with thiosemicarbazones to form heterocyclic substituted thiophene derivatives having non-steroidal anti-inflammatory activity.
Synthesis
Using ethyl acetoacetate and thionyl chloride as raw materials, the condensation reaction is carried out in the presence of a solvent. The dosage ratio of ethyl acetoacetate, thionyl chloride, and solvent is 1:1.37~2.75:2.31~4.62 by mass, the temperature of the condensation reaction is 75~95°C, and the reaction time is 5.5-9h. After stopping the reaction, evaporate most of the solvent and unreacted thionyl chloride under normal pressure, and then distill the remaining organic phase under reduced pressure to collect the 107-108°C/1.87kPa fraction to obtain Ethyl 2-chloroacetoacetate Products. The solvents used were n-heptane or, dichloroethane or toluene.
Ethyl 2-chloroacetoacetate Preparation Products And Raw materials
Raw materials
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2,4-Dimethylthiazole-5-carboxylic acid
4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID
4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE
4-METHYLOXAZOLE-5-CARBONYL CHLORIDE
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Global( 523)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| NSR Laboratories Pvt. Ltd. | +91-9866989891 +91-9000457345 | Hyderabad, India | 196 | 58 | Inquiry |
| JLS Laboratories Pvt Limited | +91 8790545679 | Hyderabad, India | 62 | 58 | Inquiry |
| LIFECHEM PHARMA | +91-9825440401 +91-9825440401 | Gujarat, India | 25 | 58 | Inquiry |
| HEMANT BIOSCIENCE | 9848655224 | Telangana, India | 40 | 58 | Inquiry |
| SRI HAIMAVATHI ORGANICS | +91-040-40030163 +91-9493978643 | Hyderabad, India | 21 | 58 | Inquiry |
| Sadasivarao g | +91 9515157878 | Hyderabad, India | 107 | 58 | Inquiry |
| ChemBioReas Life Sciences | +91-7989264158 +91-7989264158 | Hyderabad, India | 82 | 58 | Inquiry |
| AMINO ORGANICS | +919866989891 | Hyderabad, India | 275 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| GLR Innovations | 58 |
| NSR Laboratories Pvt. Ltd. | 58 |
| JLS Laboratories Pvt Limited | 58 |
| LIFECHEM PHARMA | 58 |
| HEMANT BIOSCIENCE | 58 |
| SRI HAIMAVATHI ORGANICS | 58 |
| Sadasivarao g | 58 |
| ChemBioReas Life Sciences | 58 |
| AMINO ORGANICS | 58 |
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Ethyl 2-Chloroacetoacetate >
Ethyl 2-chloroacetoacetateEthyl 2-chloroacetoacetate
Ethyl 2-chloro-3-oxobutanoate
2-Chloro-3-oxobutanoic acid, ethyl ester
2-chloroacetoacetate
2-CHLORACETYLETHYL ACETATE
Butanoic acid, 2-chloro-3-oxo-, ethyl ester
Ethyl 2-chloroacetoacetate (or)
Ethyl 2-oxo-3-piperidinecarboxylate
Apixaban Impurity SM3-1（Apixaban Impurity 3）
2-chloro ethyl aceto acetate
2-Chloroacetoacetate ethyl ester
609-15-4
KETONE
Esters
Organic Building Blocks
Building Blocks
C6 to C7
Carbonyl Compounds
Organic synthesis
Aliphatics
C6 to C7
Carbonyl Compounds