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3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Structure
CAS No.
881386-01-2
Chemical Name:
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
Synonyms
Apixaban Impurity 65;Apixaban Impurity 60;RRSYY(Fasoracetam)-4;3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one;3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone;3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2;3,3-Dichloro-1-(4-Nitrophenyl)piperidin-2-one2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl);3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one
CBNumber:
CB92594346
Molecular Formula:
C11H10Cl2N2O3
Molecular Weight:
289.11
MOL File:
881386-01-2.mol
Modify Date:
2023/8/15 17:37:19
Request For Quotation

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Properties

Boiling point 520.2±50.0 °C(Predicted)
Density 1.50
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly, Sonicated)
form Solid
pka -7.38±0.40(Predicted)
color Light Yellow to Yellow
InChI InChI=1S/C11H10Cl2N2O3/c12-11(13)6-1-7-14(10(11)16)8-2-4-9(5-3-8)15(17)18/h2-5H,1,6-7H2
InChIKey KKVYXBZVPRSWHE-UHFFFAOYSA-N
SMILES N1(C2=CC=C([N+]([O-])=O)C=C2)CCCC(Cl)(Cl)C1=O

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Chemical Properties,Uses,Production

Description

3, 3-dichloro-1 -(4-nitrophenyl) -2-piperidinone is an important pharmaceutical intermediate, as it can be used to prepare apixaban derivatives. Apixaban is a small molecular selective FXa inhibitor of pyrazole derivatives. Similar to Rivaroxaban, apixaban has two binding sites to Factor Xa, where 4-methoxyphenyl in the apixaban structure partially binds the S1 pocket of Factor Xa and aryllactam partially binds the S4 pocket of Factor Xa.

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Preparation Products And Raw materials

Raw materials

5-Chlorovaleryl chloride 1-(4-Nitrophenyl)-2-piperidinone

Preparation Products

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Suppliers

Global( 134)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEANCHEM LABORATORIES LLP +91-9951015911 +91-9951015911 Mumbai, India 281 58 Inquiry
Riddhesh Pharmachem +91-9106014993 +91-9106014993 Gujarat, India 126 58 Inquiry
ARRKEM LIFE SCIENCES PRIVATE LIMITED +91-8148739767 +91-8148739767 Telangana, India 260 58 Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Megafine Pharma (P) Ltd 09922404167 Mumbai, India 3 58 Inquiry
CLEANCHEM LABORATORIES LLP +91 98921 69560 New Delhi, India 326 58 Inquiry
Jinan Million Pharmaceutical Co., Ltd 0531-68659554 +8613031714605 China 192 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
Jinan Jianfeng Chemical Co., Ltd +8615562555968 China 234 58 Inquiry
Supplier Advantage
CLEANCHEM LABORATORIES LLP 58
Riddhesh Pharmachem 58
ARRKEM LIFE SCIENCES PRIVATE LIMITED 58
VGS SYNTHESIS PRIVATE LIMITED 58
SynZeal Research Pvt Ltd 58
Megafine Pharma (P) Ltd 58
CLEANCHEM LABORATORIES LLP 58
Jinan Million Pharmaceutical Co., Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
Jinan Jianfeng Chemical Co., Ltd 58

881386-01-2(3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one)Related Search:

Apixaban Impurity 16 (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) Apixaban-13C-D3 Apixaban IMpurity 5 (BMS-591329-01) Apixaban IMpurity(BMS-778960-01)
ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
Apixaban Apixaban IMpurity( Apixaban IMpurity 6 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban IMpurity 3
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
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3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- Apixaban Impurity 60 Apixaban Impurity 65 3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2 RRSYY(Fasoracetam)-4 3,3-Dichloro-1-(4-Nitrophenyl)piperidin-2-one2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl) 881386-01-2