Toceranib

CAS No.: 356068-94-5

Chemical Name:: Toceranib

Synonyms: CS-1158;SU-11654;Toceranib;PHA 291639;Toceranib-d8;Toceranib(SU 11654;Toceranib free base;Toceranib,PHA-291639;Toceranib DISCONTINUED;TOCERANIB;SU 11654;PHA 291639

CBNumber:: CB32518368

Molecular Formula:: C22H25FN4O2

Molecular Weight:: 396.46

MOL File:: 356068-94-5.mol

MSDS File:: SDS

Modify Date:: 2024/11/15 19:19:13

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Toceranib Properties

Melting point	>133°C (dec.)
Boiling point	596.8±50.0 °C(Predicted)
Density	1.293
storage temp.	room temp
solubility	DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
form	powder
pka	11.70±0.20(Predicted)
color	yellow to orange

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P305+P351+P338

NFPA 704

	0
2		0

Toceranib price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PZ0338	Toceranib ≥98% (HPLC)	356068-94-5	5MG	₹10954.9	2022-06-14	Buy
Sigma-Aldrich(India)	PZ0338	Toceranib ≥98% (HPLC)	356068-94-5	25MG	₹44057.75	2022-06-14	Buy

Product number	Packaging	Price	Buy
PZ0338	5MG	₹10954.9	Buy
PZ0338	25MG	₹44057.75	Buy

Toceranib Chemical Properties,Uses,Production

Biochem/physiol Actions

Toceranib (SU11654) is a protein tyrosine kinase inhibitor that selectively targets stem cell factor receptor c-kit, including all forms of mutant Kit, as well as PDGFR and VEGFR. Toceranib exhibited Ki values of 5 nM for PDGFR and 6 nM for VEGFR. Toceranib phosphate is approved for use in mast cell cancer in dogs.

Toceranib Preparation Products And Raw materials

Raw materials

1H-Pyrrole-3-carboxamide, 5-formyl-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]- Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 5-Fluoro-2-oxindole 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

3,5-Dimethylpyrrole-2,4-dicarboxylic acid 2-t-butyl ester-4-ethyl ester 1-(2-Aminoethyl)pyrrolidine

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Preparation Products

Toceranib Suppliers

Global( 117)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6100	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32080	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15354	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6391	58	Inquiry
TargetMol Chemicals Inc.		United States	38470	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
GIHI CHEMICALS CO.,LIMITED	+8618058761490	China	49979	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8467	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43340	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
TargetMol Chemicals Inc.	58
AFINE CHEMICALS LIMITED	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58

356068-94-5(Toceranib)Related Search:

Posaconazole Toceranib Phosphate

(Z)-5-(5-Fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidenemethyl)-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide SU-11654 Toceranib (Z)-5-[(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide 5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylideneMethyl)-2,4-diMethyl-1H-pyrrole-3-carboxylic Acid (2-(Pyrrolidin-1-yl)ethyl)aMide 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxaMide PHA 291639 5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylideneMethyl)-2,4-diMethyl-1H-pyrrole-3-carboxylic Acid (2-(Pyrrolidin-1-yl-d8)ethyl)aMide 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-N-[2-(1-pyrrolidinyl-d8)ethyl]-1H-pyrrole-3-carboxaMide Toceranib-d8 Toceranib (PHA 291639, SU 11654) Toceranib,PHA-291639 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrol-3-carboxamide Toceranib(SU 11654 TOCERANIB;SU 11654;PHA 291639 (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-p 5-HYDROXY-2-(4-HYDROXY-3-METHOXYPHENYL)-7-METHOXY-4H-CHROMEN-4-ONE 1H-Pyrrole-3-carboxaMide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-N-[2-(1-pyrrolidinyl)ethyl]- CS-1158 SU 11654; PHA 291639; SU11654; SU-11654; PHA-291639; PHA291639 Toceranib free base Toceranib DISCONTINUED (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrole-3-carboxamide 5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-N-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrole-3-carboxamide 356068-94-5 256068-94-5