5-Fluoro-2-oxindole
- CAS No.
- 56341-41-4
- Chemical Name:
- 5-Fluoro-2-oxindole
- Synonyms
- 5-Fluoro-1,3-dihydro-indol-2-one;5-FLUORO-2-OXYINDOLE;5-FLUOROOXINDOLE;uorooxindoL;Fluorooxindole;5-FLUROOXINDOLE;5-FLUORO-2-OXINDOLE;5-Fluorooxindole98%;5-Fluorooxindole>5-Fluor0-2-oxindole
- CBNumber:
- CB3437333
- Molecular Formula:
- C8H6FNO
- Molecular Weight:
- 151.14
- MOL File:
- 56341-41-4.mol
- Modify Date:
- 2024/6/5 17:10:12
| Melting point | 143-147 °C (lit.) |
|---|---|
| Boiling point | 307.2±42.0 °C(Predicted) |
| Density | 1.311±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Powder or Crystalline Powder |
| pka | 12.99±0.20(Predicted) |
| color | White to pale brown |
| InChI | InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11) |
| InChIKey | DDIIYGHHUMKDGI-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(F)C=C2)CC1=O |
| CAS DataBase Reference | 56341-41-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38-34 | |||||||||
| Safety Statements | 22-24/25-45-36/37/39-27-26 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
5-Fluoro-2-oxindole price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 586579 | 5-Fluoro-2-oxindole 97% | 56341-41-4 | 500MG | ₹10933.25 | 2022-06-14 | Buy |
| TCI Chemicals (India) | F0699 | 5-Fluorooxindole min. 98.0 % | 56341-41-4 | 1G | ₹6500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F0699 | 5-Fluorooxindole min. 98.0 % | 56341-41-4 | 5G | ₹16000 | 2022-05-26 | Buy |
5-Fluoro-2-oxindole Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Crystalline
Uses
5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.
Application
5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors.
Preparation
synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%.
Biological Activity
5-Fluoro-2-oxindole has anti-inflammatory, antioxidant, anxiolytic, antidepressant and antinociceptive effects and inhibits neuropathic pain. Treatment with 5-Fluoro-2-oxindole increased the expression of NQO1, HO-1, and MOR in the spinal cord and/or paw and inhibited CFA-induced up-regulation of phosphorylated MAPK, 4-HNE, NOS2, CD11b/c, and IBA-1. 5-Fluoro-2-oxindole ameliorated the local effects of morphine. Studies have revealed that 5-fluoro-2-oxindole inhibits plasticity, oxidative and inflammatory responses induced by peripheral inflammation and enhances the antinociceptive effects of morphine. Thus, the use of 5-fluoro-2-indole alone and/or in combination with morphine are two remarkable new approaches for the treatment of chronic inflammatory pain.
5-Fluoro-2-oxindole Preparation Products And Raw materials
Raw materials
1of4
chevron_rightPreparation Products
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| SPD CHEMICALS | +91-7075800742 +91-7075800742 | Hyderabad, India | 214 | 58 | Inquiry |
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| SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2688 | 50 | Inquiry |
| Dr. Jagath Reddy's Heterocyclics | 91-40-23773841 91-40-65572151 | New Delhi, India | 3886 | 42 | Inquiry |
| Stereokem, Inc. | 500039 | New Delhi, India | 293 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
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