Dimethyl malonate
![Dimethyl malonate Structure](CAS/GIF/108-59-8.gif)
- CAS No.
- 108-59-8
- Chemical Name:
- Dimethyl malonate
- Synonyms
- DMM;METHYL MALONATE;Dimethyl propanedioate;MALONIC ACID DIMETHYL ESTER;dimthyl malonate;dimethyl1,3-propanedioate;MINA-009;Malonic acid d;DIMETHYL MALONAT;DIMETHYL MALONATE
- CBNumber:
- CB3776436
- Molecular Formula:
- C5H8O4
- Molecular Weight:
- 132.11
- MOL File:
- 108-59-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/17 9:19:03
Melting point | -62 °C (lit.) |
---|---|
Boiling point | 180-181 °C (lit.) |
Density | 1.156 g/mL at 25 °C (lit.) |
vapor density | >1 (vs air) |
vapor pressure | 0.15 hPa (20 °C) |
refractive index |
n |
Flash point | 194 °F |
storage temp. | Store below +30°C. |
solubility | alcohol: miscible |
form | Liquid |
pka | 11.80±0.46(Predicted) |
color | Clear colorless |
Odor | fruity |
explosive limit | 1.3-17.4%(V) |
Water Solubility | negligible |
Merck | 14,6096 |
BRN | 774261 |
Dielectric constant | 10.4(20℃) |
Stability | Stable. Incompatible with strong oxidizing agents. Flammable. |
InChIKey | BEPAFCGSDWSTEL-UHFFFAOYSA-N |
LogP | -0.05 at 20-25℃ and pH6.4 |
CAS DataBase Reference | 108-59-8(CAS DataBase Reference) |
NIST Chemistry Reference | Propanedioic acid, dimethyl ester(108-59-8) |
EPA Substance Registry System | Dimethyl malonate (108-59-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H319 | |||||||||
Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 1 | |||||||||
RTECS | OO0950000 | |||||||||
Autoignition Temperature | 440 °C | |||||||||
Hazard Note | Irritant | |||||||||
TSCA | Yes | |||||||||
HS Code | 29171910 | |||||||||
Toxicity | LD50 orally in Rabbit: 5331 mg/kg LD50 dermal Rabbit > 5000 mg/kg | |||||||||
NFPA 704 |
|
Dimethyl malonate price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 8.00899 | Dimethyl malonate for synthesis | 108-59-8 | 100ML | ₹2160 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 8.00899 | Dimethyl malonate for synthesis | 108-59-8 | 500ML | ₹3319.99 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 8.00899 | Dimethyl malonate for synthesis | 108-59-8 | 1L | ₹4210.01 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 63380 | Dimethyl malonate purum, ≥96.0% (GC) | 108-59-8 | 250ML | ₹2814.5 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 63380 | Dimethyl malonate purum, ≥96.0% (GC) | 108-59-8 | 1L | ₹8118.75 | 2022-06-14 | Buy |
Dimethyl malonate Chemical Properties,Uses,Production
Description
Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.
Chemical Properties
Dimethyl malonate is soluble in alcohol and ether and very slightly soluble in water. It may slowly decompose.
Uses
Dimethyl malonate is a reagent used in organic synthesis. It acts as a precursor for the synthesis of mono-substituted and di-substituted acetic acid, barbiturates, vitamin B1 and vitamin B6. It is used in the pharmaceutical industry to prepare pharmaceuticals like chloroquine and butazolidin. It is involved in the synthesis of diastereomeric pure thienylpyridines by reacting with 1,3-diphenylprop-2-enyl acetate.
Application
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.
Dimethyl malonate was used in gold catalyzed oxidative esterification of glycerol, 1,2-propanediol and 1,3-propanediol.
Production Methods
Dimethyl malonate is produced via direct esterification of methanol with malonic acid under azeotropic conditions.
General Description
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.
Dimethyl malonate Preparation Products And Raw materials
Raw materials
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chevron_rightSupplier | Tel | Country | ProdList | Advantage | Inquiry |
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ADVENT CHEMBIO PRIVATE LIMITED | +91-9821524116 +91-9821524116 | Mumbai, India | 353 | 58 | Inquiry |
Cefa-Cilinas Biotics Pvt Ltd | +91-7875033155 +91-8080701561 | Maharashtra, India | 121 | 58 | Inquiry |
Aamirav Ingredients And Specialties Pvt Ltd | +91-2224980102 +91-9820077171 | Maharashtra, India | 138 | 58 | Inquiry |
GSV speciality chemicals | +91-91823634932 +91-91823634932 | Hyderabad, India | 116 | 58 | Inquiry |
Sudarshan Pharma Industries Limited. | 91-22-42221111 | Maharashtra, India | 158 | 58 | Inquiry |
Emco Dyestuff Pvt. Ltd. | +91 (22) 894 35 21 / 894 49 06 | New Delhi, India | 189 | 54 | Inquiry |
Medkem Laboratories | 91-40-23700606 | Andhra Pradesh, India | 297 | 58 | Inquiry |
Meru Chem Pvt. Ltd. | 91-22-8037401801 | Maharashtra, India | 175 | 58 | Inquiry |
Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
PNR Impex | 07942548368 | Mumbai, India | 81 | 58 | Inquiry |
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