ChemicalBook > Product Catalog >Organic Chemistry >Amides >N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide Structure
CAS No.
76820-34-3
Chemical Name:
N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide
Synonyms
Iohexol USP RC C;Iohexol Impurity 16;Iohexol Related CoMpound C;Iohexol USP Related Compound C;N,N'-Bis(2,3-dihydroxypropyl)-5-nit;Iohexol Impurity 18(Iohexol USP RC C);N,N'-Bis(2,3-Dihydorxypropyl)-5-Benzenediformamide;5-Nitro-N,N'-bis(2,3-dihydroxypropyl)isophthalamide;N,N-Bis-(2,3-dihydroxypropyl)-5-nitroisophthalamide;N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-m-phthalamide
CBNumber:
CB3258398
Molecular Formula:
C14H19N3O8
Molecular Weight:
357.32
MOL File:
76820-34-3.mol
Modify Date:
2023/4/27 16:27:43

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide Properties

Melting point >140°C (dec.)
Density 1.347 at 20℃
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form Solid
color White to Off-White
Stability Hygroscopic
LogP -1.36 at 23℃ and pH6
CAS DataBase Reference 76820-34-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code  2924296000

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide Chemical Properties,Uses,Production

Description

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide is a non-ionic organic compound that can be used as a reaction intermediate for the preparation of amidated iodinated x-ray contrast media. The amidation reaction is typically carried out in aqueous solution with an acid catalyst at room temperature for up to 24 hours. The amidation reaction condition and time can be optimized depending on the desired end product. Industrial preparation of iohexol typically involves the use of an x-ray generator and iopamidol, which is synthesized from diethylene triamine and ethylenediamine.

Chemical Properties

White to Off-White Solid.

Uses

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide is used in the preparation of X-ray contrast agents.

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-BIS(2,3-DIHYDROXYPROPYL)-2,4,6-TRIIODO-5-NITRO-1,3-BENZENEDICARBOXAMIDE N,N`-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenediformamide N,N-Bis-(2,3-dihydroxypropyl)-5-nitroisophthalamide 5-AMINO C N,N'' C BIS (2,3-DIHYDROXYPROPYL)-2,4,6-TRIIODO-1,3-BENZENEDICARBOXAMIDE N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide 5-Nitro-N,NBis(2,3-Dihydroxypropyl)-1,3-Benzenedicarbolamide Iohexol Related Compound C (50 mg) (N,N'-bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide) 5-Nitro-N,N'-bis(2,3-dihydroxypropyl)isophthalamide 5-NITRO-N,N'-BIS(2,3-DIHYDROXYPROPYL)-1,3-BENZENEDICARBOXAMIDE[IOHEXOL INTERMEDIATE] N,N'-Bis(2,3-Dihydorxypropyl)-5-Benzenediformamide 1-N,3-N-bis(2,3-dihydroxypropyl)-5-nitrobenzene-1,3-dicarboxaMide N1,N3-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxaMide N1,N3-Bis(2,3-dihydroxypropyl)-5-nitroisophthalamide Iohexol Related CoMpound C Iohexol USP Related Compound C Iohexol Impurity Ⅲ:N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide Iohexol Impurity 18(Iohexol USP RC C) N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-nitrobenzene-1,3-dicarboxamide N,N'-Bis(2,3-dihydroxypropyl)-5-nit N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxam Iohexol USP RC C 1,3-Benzenedicarboxamide, N1,N3-bis(2,3-dihydroxypropyl)-5-nitro- N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-m-phthalamide N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxami... Iohexol Related compound CQ: What is Iohexol Related compound C Q: What is the CAS Number of Iohexol Related compound C Q: What is the storage condition of Iohexol Related compound C Q: What are the applications of Iohexol Related compound C Iohexol Impurity 16 N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide 76820-34-3 C14H16I3N3O8 Aromatics Intermediates Labeling and Diagnostics Reagents