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PNU 100480

PNU 100480 Structure
CAS No.
168828-58-8
Chemical Name:
PNU 100480
Synonyms
CS-2604;U-100480;Sutezolid;PNU 100480;PF-02341272;Sutezolid 13C4;Sutezolid (PNU-100480);Sutezolid >=98% (HPLC);PNU-100480; U-100480; PF-02341272;Sutezolid (PNU-100480, PF-02341272)
CBNumber:
CB32628274
Molecular Formula:
C16H20FN3O3S
Molecular Weight:
353.41
MOL File:
168828-58-8.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:02:11
Request For Quotation

PNU 100480 Properties

Melting point 186-187°C
Boiling point 609.0±55.0 °C(Predicted)
Density 1.321±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: soluble20mg/mL, clear
form powder
pka 15.53±0.46(Predicted)
color white to beige
optical activity [α]/D -8 to -12°, c = 1 in chloroform-d

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
Safety Statements  45
NFPA 704
0
2 0

PNU 100480 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0035 Sutezolid ≥98% (HPLC) 168828-58-8 5MG ₹11420.38 2022-06-14 Buy
Sigma-Aldrich(India) PZ0035 Sutezolid ≥98% (HPLC) 168828-58-8 25MG ₹46515.03 2022-06-14 Buy
Product number Packaging Price Buy
PZ0035 5MG ₹11420.38 Buy
PZ0035 25MG ₹46515.03 Buy

PNU 100480 Chemical Properties,Uses,Production

Description

PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.

Uses

Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).

Biochem/physiol Actions

Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid.

PNU 100480 Preparation Products And Raw materials

Raw materials

Preparation Products

PNU 100480 Suppliers

Global( 70)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Sibram Pharmaceutical +91-8655777550 +91-8655777550 Maharashtra, India 244 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Labnetwork lnc. +86-27-50766799 +8618062016861 China 19994 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
Supplier Advantage
Sibram Pharmaceutical 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
Career Henan Chemica Co 58
Labnetwork lnc. 58
InvivoChem 58
LEAP CHEM CO., LTD. 58

PNU 100480 Spectrum

PNU 100480(168828-58-8)1HNMR

168828-58-8(PNU 100480)Related Search:

PF-06700841-TsOH PF-06700841 tosylate PF-06282999 PF 4618433 PF-06650833
PF-6260933 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- PF-01247324 PF 04995274 PF 05175157
PF-06281355 PF06869206
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PNU 100480 (S)-N-[[3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide Sutezolid (S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide (S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide(WXC06631) PF-02341272 Sutezolid (PNU-100480, PF-02341272) PNU-100480; U-100480; PF-02341272 U-100480 PNU 100480 - PF 02341272 | U 100480 | Sutezolid CS-2604 Sutezolid (PNU-100480) Acetamide, N-[[(5S)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]- Sutezolid >=98% (HPLC) N-[[(5S)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Sutezolid 13C4 U 100480,oxazolidinone,Antibiotic,protein,Sutezolid,synthesis,Bacterial,Inhibitor,PF 02341272,inhibit,PF02341272,U100480,antimicrobial,tuberculosis,PNU 100480,PNU100480 N-({(5S)-3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-1,3- oxazolidin-5-yl}methyl)acetamide 168828-58-8