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PF 04995274

PF 04995274 Structure
CAS No.
1331782-27-4
Chemical Name:
PF 04995274
Synonyms
PF 04995274;PF04995274;PF 04995274;PF-04995274 >=98% (HPLC);4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol;2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-;Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like
CBNumber:
CB42668576
Molecular Formula:
C23H32N2O6
Molecular Weight:
432.51
MOL File:
1331782-27-4.mol
Modify Date:
2024/7/2 8:55:08
Request For Quotation

PF 04995274 Properties

storage temp. Store at -20°C
solubility DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM)
form A crystalline solid
color White to off-white

PF 04995274 Chemical Properties,Uses,Production

Description

PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.

PF 04995274 Preparation Products And Raw materials

Raw materials

Preparation Products

PF 04995274 Suppliers

Global( 35)Suppliers
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TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48467 58 Inquiry
InvivoChem 13549236410 China 6749 58 Inquiry
BOC Sciences USA 0 65 Inquiry
DC Chemicals 021-58447131 13564518121 China 9412 58 Inquiry
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 China 5591 58 Inquiry
cjbscvictory 13348960310 13348960310 China 10011 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Nantong HI-FUTURE Biology Co., Ltd. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
InvivoChem 58
BOC Sciences 65
DC Chemicals 58
Nanjing Tengyi Biotechnology Co., Ltd 58
cjbscvictory 58

PF 04995274 Spectrum

PF 04995274(1331782-27-4)1HNMR

1331782-27-4(PF 04995274)Related Search:

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PF-01247324 PNU 100480 PF 05175157 PF-06882961 PF-5190457
PF-05212384 [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate PF-04691502 PF 477736 PF-06700841-TsOH
PF 573228 PF-3084014 PF 3644022
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PF 04995274 PF-04995274 >=98% (HPLC) 2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]- PF04995274;PF 04995274 4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like 1331782-27-4