[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

CAS No.: 1469284-79-4

Chemical Name:: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

Synonyms: PF-06424439;PF-06424439 >=98% (HPLC);PF-06424439 methanesulfonate;[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate;(R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate;acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439

CBNumber:: CB22750426

Molecular Formula:: C23H30ClN7O4S

Molecular Weight:: 536.0468

MOL File:: 1469284-79-4.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Properties

storage temp.	room temp
solubility	H2O: soluble10mg/mL, clear
form	powder
color	white to light brown

SAFETY

Risk and Safety Statements

WGK Germany	3

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PZ0233	PF-06424439 ≥98% (HPLC)	1469284-79-4	5MG	₹11009.03	2022-06-14	Buy
Sigma-Aldrich(India)	PZ0233	PF-06424439 ≥98% (HPLC)	1469284-79-4	25MG	₹44339.2	2022-06-14	Buy

Product number	Packaging	Price	Buy
PZ0233	5MG	₹11009.03	Buy
PZ0233	25MG	₹44339.2	Buy

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Chemical Properties,Uses,Production

Description

PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2; IC₅₀ = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC₅₀s = >50 μM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner. It also reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet when administered at a dose of 60 mg/kg per day.

Uses

PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2)?inhibitor:

to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
to study its effects on HeLa cells
to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells

Biochem/physiol Actions

PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Suppliers

Global( 25)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-400-6206333 18521732826	China	25013	65	Inquiry
RD International Technology Co., Limited	18024082417	China	9274	58	Inquiry
InvivoChem	13549236410	China	6747	58	Inquiry
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	China	9707	58	Inquiry
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	China	4428	55	Inquiry
BOC Sciences		USA	0	65	Inquiry

Supplier	Advantage
TargetMol Chemicals Inc.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
RD International Technology Co., Limited	58
InvivoChem	58
Shanghai EFE Biological Technology Co., Ltd.	58
Guangzhou Isun Pharmaceutical Co., Ltd	55
BOC Sciences	65

1469284-79-4([(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate)Related Search:

PF-06700841 tosylate PF-06650833 PF-05089771 (tosylate) PF-06424439 PF-06447475

PF 3644022 PF 04995274 PF-3084014 PF 573228 PF-06882961

PF-5190457 PF-05212384 PF-04691502 1H-Indole-2-carboxamide, 4-methoxy-N-[(1S)-3-methyl-1-[[[(1S)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]- PF 477736

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[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate PF-06424439 >=98% (HPLC) PF-06424439 methanesulfonate PF-06424439 acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439 (R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate 1469284-79-4