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PF 573228

PF 573228 Structure
CAS No.
869288-64-2
Chemical Name:
PF 573228
Synonyms
PF-228;CS-253;PF 573228;PF-573228, >=98%;PF-573228;PF 573228;PF 573228 USP/EP/BP;PF-573228 DISCONTINUED;Focal Adhesion Kinase Inhibitor II;PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II;Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
CBNumber:
CB42459138
Molecular Formula:
C22H20F3N5O3S
Molecular Weight:
491.49
MOL File:
869288-64-2.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

PF 573228 Properties

Melting point >242°C (dec.)
Density 1.459
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
form powder
pka 14.30±0.20(Predicted)
color white to off-white
InChIKey HESLKTSGTIBHJU-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H319
Precautionary statements  P301+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36
Safety Statements  26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
NFPA 704
0
2 0

PF 573228 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0117 PF-573228 ≥95% (HPLC) 869288-64-2 5MG ₹14667.88 2022-06-14 Buy
Sigma-Aldrich(India) PZ0117 PF-573228 ≥95% (HPLC) 869288-64-2 25MG ₹59948.85 2022-06-14 Buy
Product number Packaging Price Buy
PZ0117 5MG ₹14667.88 Buy
PZ0117 25MG ₹59948.85 Buy

PF 573228 Chemical Properties,Uses,Production

Description

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.

Uses

A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells.

Biochem/physiol Actions

PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.

PF 573228 Preparation Products And Raw materials

Raw materials

Preparation Products

PF 573228 Suppliers

Global( 138)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Coresyn Pharmatech Co., Ltd. +86-571-86626709 +86-18157142896 China 9991 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Coresyn Pharmatech Co., Ltd. 58
Nantong HI-FUTURE Biology Co., Ltd. 58

PF 573228 Spectrum

PF 573228(869288-64-2)1HNMR

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PF 573228 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone 6-[(4-((3-(Methanesulfonyl)benzyl)aMino)-5-trifluoroMethylpyriMidin-2-yl)aMino]-3,4-dihydro-1H-quinolin-2-one 6-((4-((3-(Methylsulfonyl)benzyl)aMino)-5-(trifluoroMethyl)pyriMidin-2-yl)aMino)-3,4-dihydroquinolin-2(1H)-one 2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one PF573228 PF 573228 6-[(4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one PF-228 PF-573228, >=98% PF-573228;PF 573228 3,4-DIHYDRO-6-[[4-[[[3-(METHYLSULFONYL)PHENYL]METHYL]AMINO]-5-(TRIFLUOROMETHYL)-PYRIMIDIN-2-YL]AMINO]-2(1H)-QUINOLINONE 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl] Focal Adhesion Kinase Inhibitor II CS-253 Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one PF 573228 USP/EP/BP PF-573228 DISCONTINUED PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II 869288-64-2 C22H20F3N5O3S Amines Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals