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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Angiogenesis >FAK inhibitors >PF 573228

PF 573228

PF 573228 Structure
  • ₹14667.88 - ₹59948.85
  • Product name: PF 573228
  • CAS: 869288-64-2
  • MF: C22H20F3N5O3S
  • MW: 491.49
  • EINECS:
  • MDL Number:MFCD11519967
  • Synonyms:PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone;6-[(4-((3-(Methanesulfonyl)benzyl)aMino)-5-trifluoroMethylpyriMidin-2-yl)aMino]-3,4-dihydro-1H-quinolin-2-one;6-((4-((3-(Methylsulfonyl)benzyl)aMino)-5-(trifluoroMethyl)pyriMidin-2-yl)aMino)-3,4-dihydroquinolin-2(1H)-one;2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-;Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one PF573228;PF 573228 6-[(4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one;PF-228
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0117
  • Product descriptionPF-573228 ≥95% (HPLC)
  • Packaging5MG
  • Price₹14667.88
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0117
  • Product descriptionPF-573228 ≥95% (HPLC)
  • Packaging25MG
  • Price₹59948.85
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0117 PF-573228 ≥95% (HPLC) 5MG ₹14667.88 2022-06-14 Buy
Sigma-Aldrich(India) PZ0117 PF-573228 ≥95% (HPLC) 25MG ₹59948.85 2022-06-14 Buy

Properties

Melting point :>242°C (dec.)
Density :1.459
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
pka :14.30±0.20(Predicted)
color :white to off-white
InChIKey :HESLKTSGTIBHJU-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.

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Suppliers and manufacturers

career henan chemical co
PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
₹6.68 /1KG
PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone CAS:869288-64-2
CLEARSYNTH LABS LTD. A.J Chemicals
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Dideu Industries Group Limited
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Coresyn Pharmatech Co., Ltd.
Nantong HI-FUTURE Biology Co., Ltd.