PFI-2 (hydrochloride)
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- ₹19755.63 - ₹78048.25
- Product name: PFI-2 (hydrochloride)
- CAS: 1627607-87-7
- MF: C23H26ClF4N3O3S
- MW: 535.98
- EINECS:
- MDL Number:MFCD28133380
- Synonyms:PFI-2 (hydrochloride);PFI-2 HCl salt;(R)-PFI-2 (hydrochloride);(R)-PFI-2;PFI-2; PFI2;PFI 2;R PFI-2;R-PFI2;(1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride;(R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride;macrophage,chronic kidney disease,inhibit,Histone Methyltransferase,PFI-2,Inhibitor,SET domain containing lysine methyltransferase 7 (SETD7),PFI2 hydrochloride,renal fibrosis,inflammation,PFI 2,PFI2,PFI 2 hydrochloride
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1408
- Product description(R)-PFI-2 ≥97% (HPLC)
- Packaging5MG
- Price₹19755.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1408
- Product description(R)-PFI-2 ≥97% (HPLC)
- Packaging25MG
- Price₹78048.25
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1408 | (R)-PFI-2 ≥97% (HPLC) | 5MG | ₹19755.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1408 | (R)-PFI-2 ≥97% (HPLC) | 25MG | ₹78048.25 | 2022-06-14 | Buy |
Properties
Melting point :>209°C (dec.)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage as well as the transcription factor TAF10. (R)-PFI-2 is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases. Its enantiomer, (S)-PFI-2 , is 500-fold less active (IC50 = 1 μM). See the Structural Genomics Consortium (SGC) website for more information.More related product prices
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