3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
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- ₹10879.13 - ₹44046.93
- Product name: 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- CAS: 420831-40-9
- MF: C19H21BrN2O3S
- MW: 437.35
- EINECS:
- MDL Number:MFCD03140195
- Synonyms:N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide;SIRT2 Inhibitor,AK-7;N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide SIRT2 Inhibitor,AK-7;AK 7, >=98%;3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide;AK-7;Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-;AK-7;AK7;AK 7
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0152
- Product descriptionAK-7 ≥98% (HPLC)
- Packaging5MG
- Price₹10879.13
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0152
- Product descriptionAK-7 ≥98% (HPLC)
- Packaging25MG
- Price₹44046.93
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0152 | AK-7 ≥98% (HPLC) | 5MG | ₹10879.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0152 | AK-7 ≥98% (HPLC) | 25MG | ₹44046.93 | 2022-06-14 | Buy |
Properties
Density :1.469±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥15mg/mL
form :powder
pka :12.28±0.70(Predicted)
color :white to tan
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥15mg/mL
form :powder
pka :12.28±0.70(Predicted)
color :white to tan
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases. AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). In culture, it dimishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.More related product prices
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