LY 171883
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- Product name: LY 171883
- CAS: 88107-10-2
- MF: C16H22N4O3
- MW: 318.37
- EINECS:
- MDL Number:MFCD00211057
- Synonyms:TOMELUKAST;LY-171,833;LY 171883;5-[4-4-ACETYL-3-HYDROXY-2-PROPYLPHENOXYBUTYL]-1H-TETRAZOLE;5-[4-(1-ACETYL-2-HYDROXY-3-PROPYLPHENOXY)BUTYL]-1H-TETRAZOLE;1-[2-HYDROXY-3-PROPYL-4-[4-(1H-TETRAZOL-5-YL)BUTOXY]PHENYL]ETHANONE;1-(2-hydroxy-3-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)phenyl)-ethanon ;2’-hydroxy-3’-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)-acetophenon
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Properties
Melting point :117-119℃
Boiling point :553.0±60.0 °C(Predicted)
Density :1.220±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml),
form :White solid.
pka :5.02±0.10(Predicted)
color :White
Stability :Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
CAS DataBase Reference :88107-10-2
Boiling point :553.0±60.0 °C(Predicted)
Density :1.220±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml),
form :White solid.
pka :5.02±0.10(Predicted)
color :White
Stability :Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
CAS DataBase Reference :88107-10-2
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
LY171883 is a selective, potent, orally active antagonist of the leukotriene D4 receptor. Dissociation constants (KB) for LY171883 on guinea pig ileum and parenchyma are 0.07 and 0.34 μM, respectively. LY171883 is an inhibitor of phosphodiesterase obtained from human polymorphonuclear leukocytes (IC50 of 22.6 μM) and various guinea pig tissues (IC50s range from 6.9-209 μM). At a concentration of 50-100 μM, LY171883 binds to the PPARγ nuclear receptor, inducing adipogenesis in cultured NIH3T3 fibroblasts.Related product price
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Suppliers and manufacturers
Chongqing Chemdad Co., Ltd
ANHUI WITOP BIOTECH CO., LTD
Dideu Industries Group Limited
Hebei Guanlang Biotechnology Co., Ltd.
Chengtian Fine Chemical Co., Ltd
United States Biological
Wuhan Lvjing Fenghua Biotechnology Co., Ltd.
Dongguan Walixi Chemical Co., Ltd
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