PF-562271
- ₹0
- Product name: PF-562271
- CAS: 939791-38-5
- MF: C27H26F3N7O6S2
- MW: 665.66
- EINECS:-0
- MDL Number:MFCD14105612
- Synonyms:PF-562271 PhSO3H salt;PF-562271 benzenesulfonate salt;PF-00562271 (PF-562271);N-[3-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-methanesulfonamide benzenesulfonate;PF-562271 (besylate);N-methyl-N-(3-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)methanesulfonamide benzenesulfonate;PF-00562271, >=98%;PF-562271 benzenesulfonate
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Properties
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :insoluble in EtOH; insoluble in H2O; ≥11.1 mg/mL in DMSO with gentle warming
form :solid
color :Off-white to light yellow
solubility :insoluble in EtOH; insoluble in H2O; ≥11.1 mg/mL in DMSO with gentle warming
form :solid
color :Off-white to light yellow
Safety Information
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Description
Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) are non-receptor tyrosine kinases that constitute the FAK subfamily and play a vital role in many oncogenic pathways. PF-562271 is an ATP-competitive, reversible inhibitor of FAK (IC50 = 1.5 nM) that demonstrates 10-fold reduced potency for PYK2 (IC50 = 14 nM) and >100-fold selectivity against other protein kinases. PF-562271 inhibits FAK phosphorylation with an EC50 value of 93 ng/ml in glioblastoma-bearing mice and has been shown to regress tumors in multiple xenograft models.More related product prices
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