N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
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- ₹12979.18 - ₹52263.1
- Product name: N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
- CAS: 717906-29-1
- MF: C22H21F3N6O3S
- MW: 506.5
- EINECS:
- MDL Number:MFCD16038300
- Synonyms:N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide;N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide;N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide;N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-431396;N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate;PF-431396 hydrate;PF 431396, >=98%;PF-431396;PF431396
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0185
- Product descriptionPF-431396 hydrate ≥98% (HPLC)
- Packaging5MG
- Price₹12979.18
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0185
- Product descriptionPF-431396 hydrate ≥98% (HPLC)
- Packaging25MG
- Price₹52263.1
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | PZ0185 | PF-431396 hydrate ≥98% (HPLC) | 5MG | ₹12979.18 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PZ0185 | PF-431396 hydrate ≥98% (HPLC) | 25MG | ₹52263.1 | 2022-06-14 | Buy |
Properties
Density :1.506
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :13.66±0.20(Predicted)
color :off-white to blue-gray
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :13.66±0.20(Predicted)
color :off-white to blue-gray
Safety Information
Symbol(GHS): |
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Signal word: | Danger | |||||||||||||||||||||
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Description
Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption. PF-431396 is a pyrimidine-based dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively). In ovariectomized rats, it has been shown to increase bone formation, promoting osteoblast recruitment and activity.More related product prices
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