PF-6274484
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- Product name: PF-6274484
- CAS: 1035638-91-5
- MF: C18H14ClFN4O2
- MW: 372.78
- EINECS:
- MDL Number:MFCD30182370
- Synonyms:PF-6274484;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide;2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-;PF-6274484 >=98% (HPLC);oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor;N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide
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Properties
storage temp. :Store at -20°C
solubility :DMF: 33 mg/ml; DMSO: 25 mg/ml
form :A crystalline solid
color :Light yellow to orange
solubility :DMF: 33 mg/ml; DMSO: 25 mg/ml
form :A crystalline solid
color :Light yellow to orange
Safety Information
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Description
PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.More related product prices
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