PF-06447475
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- ₹0
- Product name: PF-06447475
- CAS: 1527473-33-1
- MF: C17H15N5O
- MW: 305.33
- EINECS:
- MDL Number:MFCD28347838
- Synonyms:PF-06447475;3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile;3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile;3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile;PF 06447475;PF06447475;CS-1734;PF-06447475, >98%;Benzonitrile, 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
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Properties
Melting point :>223°C (dec.)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble10mg/mL, clear
pka :12.96±0.50(Predicted)
form :powder
color :white to beige
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble10mg/mL, clear
pka :12.96±0.50(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
PF-06447475 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 3 nM), an enzyme genetically linked to Parkinson's disease that interacts with parkin, a ligase whose loss of function leads to dopaminergic cell death. PF-06447475 has been shown to attenuate α-synuclein-induced dopaminergic neurodegeneration and neuroinflammation in G2019S-LRRK2-expressing rats.More related product prices
1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one PF-06650833 PF-06700841 tosylate PF06869206 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione 947303-87-9 PF-9366 PF-6274484 PF-562271 PF-06281355 PF-05212384 PF-3758309 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid PF 573228 717906-29-1 PF-06463922 PF 05105679 1144035-53-9 Oclacitinib PF-3450074Related product price
- 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
₹10954.9-44057.75 - PF-06650833
₹10954.9 - PF-06700841 tosylate
₹10230
