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3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Structure
  • ₹0
  • Product name: 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
  • CAS: 198474-05-4
  • MF: C12H9FN2O2
  • MW: 232.21
  • EINECS:
  • MDL Number:MFCD25121820
  • Synonyms:2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-;3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione;3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione;PF-06840003;PF 06840003;PF-06840003;EOS200271;PF-06840003 (racemate);3-(5-Fluoro-1H-indol-3-yl)-2,5-pyrrolidinedione
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :190-195 °C
Boiling point :533.2±50.0 °C(Predicted)
Density :1.464±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :9.13±0.50(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

PF-06840003 (198474-05-4) is a potent (IC50?= 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1?In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2?PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3

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Related product price

Suppliers and manufacturers

career henan chemical co
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
₹1.00 /1KG
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione CAS:198474-05-4
TargetMol Chemicals Inc.
PF-06840003
₹38.00 /2mg
PF-06840003 CAS:198474-05-4
A.J Chemicals ATK CHEMICAL COMPANY LIMITED Zhengzhou Alfa Chemical Co.,Ltd Zhejiang J&C Biological Technology Co.,Limited TargetMol Chemicals Inc. ShenZhen Trendseen Biological Technology Co.,Ltd. Aceschem Inc. LEAPCHEM CO., LTD.