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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Angiogenesis >FAK inhibitors >PF-562271

PF-562271

PF-562271 Structure
CAS No.
939791-38-5
Chemical Name:
PF-562271
Synonyms
PF-00562271, >=98%;PF-562271 (besylate);PF-00562271 Besylate;PF-562271 PhSO3H salt;PF-00562271 (PF-562271);PF-562271 benzenesulfonate;LKLWTLXTOVZFAE-UHFFFAOYSA-N;PF-562271 besylate PF562271;PF 562271 Benzenesulfonic acid;PF-562271 benzenesulfonate salt
CBNumber:
CB22535568
Molecular Formula:
C27H26F3N7O6S2
Molecular Weight:
665.66
MOL File:
939791-38-5.mol
Modify Date:
2024/7/2 8:55:03
Request For Quotation

PF-562271 Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility insoluble in EtOH; insoluble in H2O; ≥11.1 mg/mL in DMSO with gentle warming
form solid
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362+P364-P403+P233-P501c

PF-562271 Chemical Properties,Uses,Production

Description

Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) are non-receptor tyrosine kinases that constitute the FAK subfamily and play a vital role in many oncogenic pathways. PF-562271 is an ATP-competitive, reversible inhibitor of FAK (IC50 = 1.5 nM) that demonstrates 10-fold reduced potency for PYK2 (IC50 = 14 nM) and >100-fold selectivity against other protein kinases. PF-562271 inhibits FAK phosphorylation with an EC50 value of 93 ng/ml in glioblastoma-bearing mice and has been shown to regress tumors in multiple xenograft models.

Uses

PF 562271 Besylate is the besylate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK).

PF-562271 Preparation Products And Raw materials

Raw materials

2,4-Dichloro-5-trifluoromethylpyrimidine Trifluorothymine PF-562271 Benzenesulfonic acid

Preparation Products

PF-562271 Suppliers

Global( 87)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58

PF-562271 Spectrum

PF-562271(939791-38-5)1HNMR

939791-38-5(PF-562271)Related Search:

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PF-562271 PhSO3H salt PF-562271 benzenesulfonate salt PF-00562271 (PF-562271) N-[3-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-methanesulfonamide benzenesulfonate PF-562271 (besylate) N-methyl-N-(3-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)methanesulfonamide benzenesulfonate PF-00562271, >=98% PF-562271 benzenesulfonate PF-00562271 benzenesulfonate salt PF-00562271 benzesulfonate-data LKLWTLXTOVZFAE-UHFFFAOYSA-N N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide monobesylate PF562271 BESYLATE;PF 562271 BESYLATE PF-00562271 Besylate PF-562271 (benzesulfonate salt) PF-562271 besylate PF562271 PF 562271 Benzenesulfonic acid 939791-38-5 C21H20F3N7O3SC6H6O3S Inhibitors