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6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Structure
CAS No.
1467057-23-3
Chemical Name:
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
Synonyms
CS-2760;EOS-61684;PF 6409577;PF-06409577;PF 06409577;PF06409577;PF-06409577 >=98% (HPLC);PF-06409577;PF 06409577;PF06409577;6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid;1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-;Inhibitor,AMP-activated protein kinase,PF-06409577,AMPK,PF06409577,inhibit
CBNumber:
CB33142869
Molecular Formula:
C19H16ClNO3
Molecular Weight:
341.79
MOL File:
1467057-23-3.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Properties

Boiling point 610.9±55.0 °C(Predicted)
Density 1.468±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: soluble
pka 3.60±0.30(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338
NFPA 704
0
2 0

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0319 PF-06409577 ≥98% (HPLC) 1467057-23-3 5MG ₹10954.9 2022-06-14 Buy
Sigma-Aldrich(India) PZ0319 PF-06409577 ≥98% (HPLC) 1467057-23-3 25MG ₹44057.75 2022-06-14 Buy
Product number Packaging Price Buy
PZ0319 5MG ₹10954.9 Buy
PZ0319 25MG ₹44057.75 Buy

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Chemical Properties,Uses,Production

Description

PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (Kd = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC50s = 2.18-7.03 nM) over β2-containing isoforms (EC50s = ≥10 μM). PF-06409577 has an EC50 value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.

Uses

PF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy.

General Description

PF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole.

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Preparation Products And Raw materials

Raw materials

5-bromo-6-chloro-1H-Indole-3-carboxaldehyde methyl 5-bromo-6-chloro-1H-indole-3-carboxylate 1-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)cyclobutanol 1-(4-bromophenyl)cyclobutanol [4-(1-hydroxycyclobutyl)phenyl]boronic acid
1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutanol 5-Bromo-6-chloro-1H-indole 1-Bromo-4-iodobenzene 1,4-Dibromobenzene
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Preparation Products

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Suppliers

Global( 67)Suppliers
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A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
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Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
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LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Sichuan Biosynce Pharmatech Co., Ltd. +8619950309693 China 4874 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
InvivoChem 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
LEAPCHEM CO., LTD. 58
Sichuan Biosynce Pharmatech Co., Ltd. 58

1467057-23-3(6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid)Related Search:

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6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid PF-06409577 CS-2760 PF-06409577;PF 06409577;PF06409577 EOS-61684 PF 06409577;PF06409577 PF 6409577 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- PF-06409577 >=98% (HPLC) Inhibitor,AMP-activated protein kinase,PF-06409577,AMPK,PF06409577,inhibit 1467057-23-3