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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >PF-05212384

PF-05212384

PF-05212384 Structure
CAS No.
1197160-78-3
Chemical Name:
PF-05212384
Synonyms
CS-46;PKI587;PF-05212384;GEDATOLISIB;PKI-587;PKI 587 PF 05212384;PF-05212384 (PKI-587);PF-05212384 USP/EP/BP;PKI-587 ( Gedatolisib );GEDATOLISIB;PF-05212384;Gedatolisib (PF-05212384, PKI-587)
CBNumber:
CB32500950
Molecular Formula:
C32H41N9O4
Molecular Weight:
615.73
MOL File:
1197160-78-3.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:15
Request For Quotation

PF-05212384 Properties

Melting point 226-227°C
Density 1.364
storage temp. Refrigerator
solubility DMSO
pka 13.97±0.70(Predicted)
form Solid
color Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29349990

PF-05212384 Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Enzyme inhibitor

This dual PI3K/mTOR (phosphoinositide-3-kinase and mammalian target of rapamycin) signal-transduction pathway inhibitor and antineoplastic agent (F.Wt. = 615.73; CAS 1197160-78-3); Solubility (25°C): 2 mg/mL DMSO, <1 mg/mL Water), also known as PF-05212384 and systematically as 1-(4- (4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino- 1,3,5-triazin-2-yl)phenyl)urea, inhibits PI3K-α, PI3K-γ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM, respectively. PKI-587 also inhibits mutant forms of PI3Kα, including the PI3Kα-H1047R and PI3Kα-E545K with IC50 of 0.6 nM and 0.6 nM, respectively.

PF-05212384 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-05212384 Suppliers

Global( 161)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Wuhan Nutra Biotechnology Co.,Ltd +8617786394783 China 300 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Wuhan Nutra Biotechnology Co.,Ltd 58

PF-05212384 Spectrum

PF-05212384(1197160-78-3)1HNMR

1197160-78-3(PF-05212384)Related Search:

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IPI 145 PD 0332991 HCl Rapamycin
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PF-05212384 PKI587 N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]phenyl]urea 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea Gedatolisib (PF-05212384, PKI-587) N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]phenyl]urea PF-05212384 (PKI-587) PKI-587 N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]phenyl]urea PKI-587 ( Gedatolisib ) GEDATOLISIB;PKI-587 GEDATOLISIB (PF-05212384, PKI-587);PKI-587 1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl PF-05212384 (PKI-587) [(2R)-3-BENZOYLOXY-4,4-DIFLUORO-5-OXOOXOLAN-2-YL]METHYL BENZOATE CS-46 PKI 587 PF 05212384 PF-05212384; PKI587; PKI 587;PKI-587;PF-05212384;PF-05212384 GEDATOLISIB;PF-05212384 1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea Urea, N-[4-[[4-(dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]- PF-05212384 USP/EP/BP mTOR,Mammalian target of Rapamycin,Inhibitor,PI3K,PF 05212384,Gedatolisib,Phosphoinositide 3-kinase,PKI587,PKI 587,inhibit,PF05212384 1197160-78-3 C32H41N9O4 Akt mTOR PI3K PI3K/Akt/mTOR Inhibitors