ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Histone Methyltransferase Inhibitors >BIX 01294

BIX 01294

CAS No.: 1392399-03-9

Chemical Name:: BIX 01294

Synonyms: CS-1418;BIX 01204;BIX01294 HCl;BIX01294 triHCl;BIX 01294 USP/EP/BP;BIX01294 hydrochloride;BIX01294 3hydrochloride;Trihydrochloride Hydrate;BIX 01294 Trihydrochloride Hydrate;BIX01294 hydrochloride BIX-01294 HCL

CBNumber:: CB92677401

Molecular Formula:: C28H41Cl3N6O2

Molecular Weight:: 600.02314

MOL File:: 1392399-03-9.mol

Modify Date:: 2023/9/20 16:43:00

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BIX 01294 Properties

storage temp.	Inert atmosphere,2-8°C
solubility	H2O: >20mg/mL
form	powder
color	white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2933.99.8290

BIX 01294 price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	B9311	BIX 01294 trihydrochloride hydrate ≥98% (HPLC), powder	1392399-03-9	5MG	₹19539.13	2022-06-14	Buy
Sigma-Aldrich(India)	B9311	BIX 01294 trihydrochloride hydrate ≥98% (HPLC), powder	1392399-03-9	25MG	₹78059.08	2022-06-14	Buy
TCI Chemicals (India)	B4211	BIX 01294 Trihydrochloride Hydrate	1392399-03-9	25MG	₹16200	2022-05-26	Buy

Product number	Packaging	Price	Buy
B9311	5MG	₹19539.13	Buy
B9311	25MG	₹78059.08	Buy
B4211	25MG	₹16200	Buy

BIX 01294 Chemical Properties,Uses,Production

Uses

BIX 01294 trihydrochloride hydrate has been used:

as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
to investigate the role of G9a in neuroblastoma tumor growth
as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines

General Description

BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.

Biochem/physiol Actions

BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.

BIX 01294 Preparation Products And Raw materials

Raw materials

Preparation Products

BIX 01294 Suppliers

Global( 87)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26216	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
LEAP CHEM CO., LTD.	+86-852-30606658	China	24738	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry

Supplier	Advantage
TCI Chemicals (India) Pvt. Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

BIX 01294 Spectrum

BIX 01294(1392399-03-9)¹HNMR

1392399-03-9(BIX 01294)Related Search:

Tazemetostat (EPZ-6438) GSK J4 HCl GSK 343 (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol MM-102

OG-L002

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BIX 01294 Trihydrochloride Hydrate 4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-, hydrochloride (1:3) 2-(Hexahydro-4-Methyl-1H-1,4-Diazepin-1-yl)-6,7-Dimethoxy-[1-(Phenylmethyl)-4-Piperidynyl]-4-Quinazolinamine Trihydrochloride BIX01294 hydrochloride BIX01294 hydrochloride BIX01294 3hydrochloride Trihydrochloride Hydrate N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine BIX 01204 CS-1418 N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine hydrochloride N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan -1-yl)-4-quinazolinamine trihydrochloride BIX 01294 Trihydrochloride Hydrate> BIX01294 HCl BIX 01294 USP/EP/BP N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride BIX01294 triHCl BIX01294 hydrochloride BIX-01294 HCL SUV39H1(H320R),BIX-01294 trihydrochloride,p21,recurrent,Cdkn1a,MLKL,H3K9me3,inhibit,Histone Methyltransferase,PRMT1,p53,Autophagy,Inhibitor,H3K9me2,BIX 01294 trihydrochloride,Gadd45a,BIX01294 trihydrochloride 1392399-03-9 C28H38N6O23HClxH2O Inhibitors