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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Histone Demethylase inhibitors >OG-L002

OG-L002

OG-L002 Structure
CAS No.
1357302-64-7
Chemical Name:
OG-L002
Synonyms
CS-830;OG-L002;OG-L002 USP/EP/BP;OGL002;OG L002;OGL-002;4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol;4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol;4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o;OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol
CBNumber:
CB12677399
Molecular Formula:
C15H15NO
Molecular Weight:
225.29
MOL File:
1357302-64-7.mol
Modify Date:
2024/7/2 8:55:00
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OG-L002 Properties

Boiling point 416.7±45.0 °C(Predicted)
Density 1.193±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; ≥22.5 mg/mL in DMSO; ≥6.82 mg/mL in EtOH
form solid
pka 9.78±0.10(Predicted)
color White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

OG-L002 Chemical Properties,Uses,Production

Description

Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 μM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 μM). It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes. OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells. It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.

Uses

OG-L002 is a novel, potent, and selective LSD1/KDM1A inhibitor that epigenetically blocks the herpes simplex lytic replication and reactivation from latency.

OG-L002 Preparation Products And Raw materials

Raw materials

Preparation Products

OG-L002 Suppliers

Global( 98)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24639 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Shanghai Boyi Biotechnology Co., Ltd. 021-58351080 15800446246 CHINA 5417 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Shanghai Boyi Biotechnology Co., Ltd. 58

OG-L002 Spectrum

OG-L002(1357302-64-7)1HNMR

1357302-64-7(OG-L002)Related Search:

BIX 01294 Tazemetostat (EPZ-6438) GSK J4 HCl 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol
MM-102
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OG-L002 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o OG-L002 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]- OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol 4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol 4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol OGL002;OG L002;OGL-002 CS-830 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]- OG-L002 USP/EP/BP 4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol 1357302-64-7 Inhibitors