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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Histone Demethylase inhibitors >GSK J4 HCl

GSK J4 HCl

GSK J4 HCl Structure
CAS No.
1373423-53-0
Chemical Name:
GSK J4 HCl
Synonyms
GSK-J4;GSK J4;CS-1667;CS-2143;GSK J4 HCl;6-Triiodophenol;GSK J4 free base;GSKJ4HCL(free base);GSK J4 HCl USP/EP/BP;GSK-J4, 10 mM in DMSO
CBNumber:
CB62665155
Molecular Formula:
C24H27N5O2
Molecular Weight:
417.5
MOL File:
1373423-53-0.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
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GSK J4 HCl Properties

Boiling point 581.2±50.0 °C(Predicted)
Density 1.216±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble20mg/mL, clear
pka 5.95±0.10(Predicted)
form Tan semi-solid
color white to beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey WBKCKEHGXNWYMO-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3

GSK J4 HCl price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0701 GSK-J4 ≥98% (HPLC) 1373423-53-0 5MG ₹11677.2 2022-06-14 Buy
Sigma-Aldrich(India) SML0701 GSK-J4 ≥98% (HPLC) 1373423-53-0 25MG ₹47552.4 2022-06-14 Buy
Sigma-Aldrich(India) 420205 Histone Lysine Demethylase Inhibitor VIII, GSK-J4 - CAS 1373423-53-0 - Calbiochem Histone Lysine Demethylase Inhibitor VIII, GSK-J4, CAS 1373423-53-0, is converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (~ 1373423-53-0 10MG ₹20250 2022-06-14 Buy
Product number Packaging Price Buy
SML0701 5MG ₹11677.2 Buy
SML0701 25MG ₹47552.4 Buy
420205 10MG ₹20250 Buy

GSK J4 HCl Chemical Properties,Uses,Production

Uses

GSK-J4 has been used to study the effect of KDM2B (Jumonji (JmjC) domain histone 3 lysine 36 (H3K36) di-demethylase) inhibition on the survival and DNA repair potential of glioblastoma cells. It has also been used in sulforhodamine B (SRB) cell growth assay and cell viability assay.

Biochem/physiol Actions

GSK-J4 is cell permeable prodrug rapidly hydrolysed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor. Jumonji C domain-containing histone demethylases (JHDMs) are Fe(II) and α-ketoglutarate dependent enzymes that oxygenate methylated histone lysine residues and thereby cause their demethylation. GSK-J1 is selective for the KDM6 subfamily members JMJD3 and UTX with an IC50 of 60 nM in a JMJD3 assay, and is inactive against other demethylases of the JMJ family and over 100 tested kinases and histone deacetylases. The prodrug GSK-J4 inhibited TNF-α production with an IC50 of 9 μM in LPS-stimulated human macrophages and blocked the production of TNF-α by macrophages derived from patients with rheumatoid arthritis. For characterization details for GSK-J4 and full characterization details for GSK-J1, please visit the GSK-J1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

GSK J4 HCl Preparation Products And Raw materials

Raw materials

ethyl 3-((6-chloro-2-(pyridin-2-yl)pyriMidin-4-yl)aMino)propanoate 4,6-DICHLORO-2-(2-PYRIDINYL)PYRIMIDINE 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE

Preparation Products

GSK J4 HCl Suppliers

Global( 133)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29808 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22854 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3135 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58

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GSK J4 HCl Spectrum

GSK J4 HCl(1373423-53-0)1HNMR

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GSK J4 N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester GSK J4 HCl N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine ethyl ester β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester, hydrochloride (1:1) Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)prop Histone Lysine Demethylase Inhibitor VIII, GSK-J4 ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate CS-2143 CS-1667 H3K27 histone demethylase inhibitor J4 HCl Histone Lysine Demethylase Inhibitor VIII, GSK-J4 - CAS 1373423-53-0 - Calbiochem GSK J4 free base GSKJ4HCL(free base) β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester GSK J4 HCl USP/EP/BP GSK J4 HCl (GSKJ4 HCl) 6-Triiodophenol GSK-J4 GSK-J4, histone demethylase JMJD3/UTX inhibitor GSK-J4, 10 mM in DMSO 1373423-53-0 C24H27N5O2HCl Inhibitor Inhibitors API