Name: GSK J4 HCl
Brand: chemicalbook
SKU: 1373423-53-0

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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Epigenetics >Histone Demethylase inhibitors >GSK J4 HCl

GSK J4 HCl

₹11677.2 - ₹47552.4
Product name: GSK J4 HCl
CAS: 1373423-53-0
MF: C24H27N5O2
MW: 417.5
EINECS:
MDL Number:MFCD22683852
Synonyms:GSK J4;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester;GSK J4 HCl;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine ethyl ester;β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester, hydrochloride (1:1);Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate;Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)prop;Histone Lysine Demethylase Inhibitor VIII, GSK-J4

Price3 Properties Safety Information Description

3 prices

Selected condition：

Brand

Sigma-Aldrich(India)

Package

5MG
10MG
25MG

ManufacturerSigma-Aldrich(India)
Product numberSML0701
Product descriptionGSK-J4 ≥98% (HPLC)
Packaging5MG
Price₹11677.2
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product number420205
Product descriptionHistone Lysine Demethylase Inhibitor VIII, GSK-J4 - CAS 1373423-53-0 - Calbiochem Histone Lysine Demethylase Inhibitor VIII, GSK-J4, CAS 1373423-53-0, is converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (~
Packaging10MG
Price₹20250
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberSML0701
Product descriptionGSK-J4 ≥98% (HPLC)
Packaging25MG
Price₹47552.4
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0701	GSK-J4 ≥98% (HPLC)	5MG	₹11677.2	2022-06-14	Buy
Sigma-Aldrich(India)	420205	Histone Lysine Demethylase Inhibitor VIII, GSK-J4 - CAS 1373423-53-0 - Calbiochem Histone Lysine Demethylase Inhibitor VIII, GSK-J4, CAS 1373423-53-0, is converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (~	10MG	₹20250	2022-06-14	Buy
Sigma-Aldrich(India)	SML0701	GSK-J4 ≥98% (HPLC)	25MG	₹47552.4	2022-06-14	Buy

Properties

Boiling point :581.2±50.0 °C(Predicted)
Density :1.216±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :5.95±0.10(Predicted)
form :Tan semi-solid
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :WBKCKEHGXNWYMO-UHFFFAOYSA-N

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321	Specific treatment (see … on this label).
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P362	Take off contaminated clothing and wash before reuse.

Description

GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (cat.# 10-1393).1 GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.2

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Suppliers and manufacturers

career henan chemical co

₹1.00 /1KG
ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate CAS:1373423-53-0

TargetMol Chemicals Inc.

₹51.00 /2mg
GSK-J4 CAS:1373423-53-0

CLEARSYNTH LABS LTD.

ATK CHEMICAL COMPANY LIMITED

Dideu Industries Group Limited

Zhejiang J&C Biological Technology Co.,Limited

InvivoChem

Nantong HI-FUTURE Biology Co., Ltd.