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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >TRICHOSTATIN A

TRICHOSTATIN A

TRICHOSTATIN A Structure
  • ₹7820.4 - ₹82811.25
  • Product name: TRICHOSTATIN A
  • CAS: 58880-19-6
  • MF: C17H22N2O3
  • MW: 302.37
  • EINECS:611-758-2
  • MDL Number:MFCD03848392
  • Synonyms:7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide ;7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID;Trichostatin A from Streptomyces platensis;[r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide;7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE;TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
8 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1MG
  • 10MG
  • 200μL
  • 5MG
  • 50MG
  • ManufacturerTCI Chemicals (India)
  • Product numberT2477
  • Product descriptionTrichostatin A
  • Packaging10MG
  • Price₹10800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2477
  • Product descriptionTrichostatin A
  • Packaging50MG
  • Price₹24500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT1952
  • Product descriptionTrichostatin A, Ready Made Solution 5?mM in DMSO (0.2 μm-filtered), from Streptomyces sp.
  • Packaging200μL
  • Price₹7820.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV900931
  • Product descriptionTrichostatin A Vetec?, reagent grade, from Streptomyces sp., ≥98%
  • Packaging1MG
  • Price₹21834.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT8552
  • Product descriptionTrichostatin A ≥98% (HPLC), from Streptomyces sp.
  • Packaging1MG
  • Price₹24832.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number647925
  • Product descriptionTrichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem A potent and reversible, cell-permeable inhibitor of histone deacetylase.
  • Packaging1MG
  • Price₹28660
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV900931
  • Product descriptionTrichostatin A Vetec?, reagent grade, from Streptomyces sp., ≥98%
  • Packaging5MG
  • Price₹40041.68
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT8552
  • Product descriptionTrichostatin A ≥98% (HPLC), from Streptomyces sp.
  • Packaging5MG
  • Price₹82811.25
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) T2477 Trichostatin A 10MG ₹10800 2022-05-26 Buy
TCI Chemicals (India) T2477 Trichostatin A 50MG ₹24500 2022-05-26 Buy
Sigma-Aldrich(India) T1952 Trichostatin A, Ready Made Solution 5?mM in DMSO (0.2 μm-filtered), from Streptomyces sp. 200μL ₹7820.4 2022-06-14 Buy
Sigma-Aldrich(India) V900931 Trichostatin A Vetec?, reagent grade, from Streptomyces sp., ≥98% 1MG ₹21834.03 2022-06-14 Buy
Sigma-Aldrich(India) T8552 Trichostatin A ≥98% (HPLC), from Streptomyces sp. 1MG ₹24832.55 2022-06-14 Buy
Sigma-Aldrich(India) 647925 Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem A potent and reversible, cell-permeable inhibitor of histone deacetylase. 1MG ₹28660 2022-06-14 Buy
Sigma-Aldrich(India) V900931 Trichostatin A Vetec?, reagent grade, from Streptomyces sp., ≥98% 5MG ₹40041.68 2022-06-14 Buy
Sigma-Aldrich(India) T8552 Trichostatin A ≥98% (HPLC), from Streptomyces sp. 5MG ₹82811.25 2022-06-14 Buy

Properties

Melting point :140-143℃
alpha :D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
Density :1.139
refractive index :136 ° (C=0.3, MeOH)
storage temp. :-20°C
solubility :ethanol: 1 mg/mL
pka :8.93±0.23(Predicted)
form :Off-white lyophilized solid
color :Tan
Merck :14,9649
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :ZWGICMNKJBUOHG-RCXLNATQSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of the HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.

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