JIB-04
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- ₹11550.28 - ₹46558.33
- Product name: JIB-04
- CAS: 199596-05-9
- MF: C17H13ClN4
- MW: 308.76
- EINECS:-0
- MDL Number:MFCD26936344
- Synonyms:JIB-04;JIB-04 (NSC 693627);JIB04/JIB-04;5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone;(E)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE;5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine;NSC 693627;5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone JIB-04(NSC 693627)
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0808
- Product descriptionJIB-04 ≥98% (HPLC)
- Packaging5MG
- Price₹11550.28
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0808
- Product descriptionJIB-04 ≥98% (HPLC)
- Packaging25MG
- Price₹46558.33
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0808 | JIB-04 ≥98% (HPLC) | 5MG | ₹11550.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0808 | JIB-04 ≥98% (HPLC) | 25MG | ₹46558.33 | 2022-06-14 | Buy |
Properties
Boiling point :472.9±55.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :11.00±0.10(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey :YHHFKWKMXWRVTJ-OQKWZONESA-N
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :11.00±0.10(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey :YHHFKWKMXWRVTJ-OQKWZONESA-N
Safety Information
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Description
JIB-04 is a pyridine hydrazone that broadly inhibits Jumonji histone demethylases (IC50s values = 230, 340, 435, 445, 855 and 1,100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3, and JMJD2C, respectively). It does not inhibit histone deacetylases and has minimal effect on the iron-containing enzymes methylcytosine dioxygenase TET1 and hypoxia-inducible factor prolyl hydroxylase 2. JIB-04 inhibits Jumonji demethylase activity, alters gene expression, and blocks viability of cancer cells but not in patient-matched normal cells. It also inhibits Jumonji demethylase activity in cancer cells in vivo, resulting in reduced tumor burden and prolonged survival.More related product prices
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