Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cell Cycle >Chk inhibitor >PF 477736

PF 477736

PF 477736 Structure
CAS No.
952021-60-2
Chemical Name:
PF 477736
Synonyms
PF-736;CS-237;PF0044736;PF 477736;PF0477736;PF-0044736;PF-00477736;PF-736,PF-00477736;PF-477736 PF477736;PF 477736 USP/EP/BP
CBNumber:
CB02535690
Molecular Formula:
C22H25N7O2
Molecular Weight:
419.49
MOL File:
952021-60-2.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

PF 477736 Properties

Density 1.56
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
form powder
pka 11.79±0.20(Predicted)
color yellow
InChIKey NDEXUOWTGYUVGA-LJQANCHMSA-N

SAFETY

Risk and Safety Statements

WGK Germany  3

PF 477736 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0186 PF-477736 ≥98% (HPLC) 952021-60-2 5MG ₹12730.2 2022-06-14 Buy
Sigma-Aldrich(India) PZ0186 PF-477736 ≥98% (HPLC) 952021-60-2 25MG ₹51884.23 2022-06-14 Buy
Product number Packaging Price Buy
PZ0186 5MG ₹12730.2 Buy
PZ0186 25MG ₹51884.23 Buy

PF 477736 Chemical Properties,Uses,Production

Description

Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.

Uses

P293850 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage.

Biochem/physiol Actions

PF-477736 may be effectively used to resensitize platinum resistant ovarian cancer cells. PF-477736 alone or in combination with other chemotherapeutic agents may be used to treat triple-negative breast cancer.

PF 477736 Preparation Products And Raw materials

Raw materials

Preparation Products

PF 477736 Suppliers

Global( 101)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29899 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 23499 58 Inquiry
Wuhan Nutra Biotechnology Co.,Ltd +8617786394783 China 300 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nanjing Doge Biomedical Technology Co., Ltd +86-25-58227606 +86-15305155328 China 4128 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
Dideu Industries Group Limited 58
Wuhan Nutra Biotechnology Co.,Ltd 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Nanjing Doge Biomedical Technology Co., Ltd 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58

952021-60-2(PF 477736)Related Search:

PF-05089771 (tosylate) PF-06424439 PF-06447475 PF 3644022 PF 04995274
PF-3084014 PF 573228 PF-06882961 PF-5190457 PF-05212384
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate PF-04691502 Sunitinib LY2603618 MK-8776 (SCH 900776)
AZD7762 VE 822 PF-06650833
chevron_left

1of4

chevron_right
PF 477736 PF-00477736 PF-736 (αR)-α-AMino-N-[5,6-dihydro-2-(1-Methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetaMide PF 477736(PF-0044736) (2R)-2-aMino-2-cyclohexyl-N-[2-(1-Methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7,11-pentaen-6-yl]acetaMide PF0044736 PF-0044736 (alphaR)-alpha-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetamide Cyclohexaneacetamide, α-amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-, (αR)- PF-736,PF-00477736 (alphaR)-alpha-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetamide PF-477736 (2R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide α-amino-n-[5,6-dihydro-2-(1-methyl-1h-pyrazol-4-yl)-6-oxo-1h-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide PF0477736 (R)-2-AMINO-2-CYCLOHEXYL-N-[2-(1-METHYL-1H-PYRAZOL-4-YL)-6-OXO-5,6-DIHYDRO-1H-[1,2]DIAZEPINO[4,5,6-CD]INDOL-8-YL]-ACETAMIDE (R)-2-Amino-2-cyclohexyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4 NDEXUOWTGYUVGA-LJQANCHMSA-N CS-237 PF 477736;PF-477736;PF477736 PF 477736 - PF 00477736 PF 477736 USP/EP/BP PF-477736 PF477736 (R)-2-Amino-2-cyclohexyl-N-(5-(1-methyl-1H-pyrazol-4-yl)-1-oxo-2,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide 952021-60-2 952021-60-3 C22H25N7O22ClH Amines Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals