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Sunitinib

Sunitinib Structure
CAS No.
557795-19-4
Chemical Name:
Sunitinib
Synonyms
SUNITINIB BASE;SUNITINIB MALEATE;SNTI;Suniti;Sutini;SU-11248;sunitinib;Sutent-d4;SU-11248-d4;SUNITINIB-D4
CBNumber:
CB9728174
Molecular Formula:
C22H27FN4O2
Molecular Weight:
398.47
MOL File:
557795-19-4.mol
Modify Date:
2024/7/17 18:13:28
Request For Quotation

Sunitinib Properties

Melting point 189-191°C
Boiling point 572.1±50.0 °C(Predicted)
Density 1.2
Flash point 299.8℃
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 8.5(at 25℃)
form Solid
color Yellow to Dark Orange
CAS DataBase Reference 557795-19-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
Safety Statements  24/25
HS Code  29337900

Sunitinib Chemical Properties,Uses,Production

Description

Sunitinib is an inhibitor of multiple receptor tyrosine kinases (RTKs) involved in tumor proliferation and angiogenesis, including platelet-derived growth factor receptors (PDGFR), vascular endothelial growth factor receptors (VEGFR), and stem cell factor receptor (KIT). It was launched as an oral treatment for gastrointestinal stromal tumors (GIST) and advanced renal-cell carcinoma (RCC). In vitro, sunitib inhibits VEGFR2, PDGFRα, PDGFRβ, KIT, and FLT3 receptors with IC50 values in the 4–14nM range, and the ligand-dependent autophosphorylation of VEGFR2 and PDGFRb with IC50s of approximately 10 nM. In addition, it inhibits the growth of tumor cells expressing dysregulated target RTKs in vitro and inhibits PDGFRb- and VEGFR2-dependent tumor angiogenesis in vivo. Sunitinib exhibits broad and potent antitumor activity, causing regression in murine models of human epidermal (A431), colon (Colo205 and HT-29), lung (NCI-H226 and H460), breast (MDA-MB-435), prostate (PC3-3M-luc), and renal (786-O) cancers, and suppressing or delaying the growth of many others, including the C6 rat and SF763 T human glioma xenografts and B16 melanoma lung cancer.

Chemical Properties

Yellow Solid

Uses

Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Characteristics

Class: receptor tyrosine kinase
Treatment: RCC, GIST
Elimination half-life = 70 h
Protein binding = 95%

Sunitinib Preparation Products And Raw materials

Raw materials

5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid N,N-Diethylethylenediamine

Preparation Products

Sunitinib Suppliers

Global( 415)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
J S LABS +91-7330612784 +91-7330612784 Tamil Nadu, India 160 58 Inquiry
Humble Healthcare Limited +91-9720093000 +91-8006400378 Uttar Pradesh, India 141 58 Inquiry
Beta Drugs +91-9316590666 +91-7015991921 Haryana, India 34 58 Inquiry
Shreyaa Medilife Private Limited +91-6354474696 +91-9879513108 Ahmedabad, India 67 58 Inquiry
Laurus Labs Ltd +91-4066594333 +91-4039804333 Telangana, India 50 58 Inquiry
Sakar Healthcare +91-8976292690 +91-9967572302 Gujarat, India 47 58 Inquiry
AKASH PHARMA EXPORTS +91-9388123451 +91-9846039283 Kerela, India 470 58 Inquiry
Hardik Onco Care 08047642620 Ahmedabad, India 7 58 Inquiry
Medicare Remedies Private Limited 08048957356 Mumbai, India 8 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Supplier Advantage
J S LABS 58
Humble Healthcare Limited 58
Beta Drugs 58
Shreyaa Medilife Private Limited 58
Laurus Labs Ltd 58
Sakar Healthcare 58
AKASH PHARMA EXPORTS 58
Hardik Onco Care 58
Medicare Remedies Private Limited 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58

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Sunitinib Spectrum

Sunitinib(557795-19-4)1HNMR

557795-19-4(Sunitinib)Related Search:

Dasatinib monohydrate Methyl 2-hydroxyethyl cellulose Ethylparaben Gefitinib Lapatinib
Ethyl cyanoacetate Ethyl acrylate Teniposide Erlotinib Ethanol
N,N-Dimethyl-1,4-phenylenediamine Tris(hydroxymethyl)aminomethane Ethyl acetate Imatinib ISOXADIFEN-ETHYL
Dihydromyrcenol Imatinib mesylate Sunitinib Malate
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SU-11248 N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2- dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Malate N-[2-DiethylaMino(ethyl-d4)]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carboxaMide SU-11248-d4 Sutent-d4 (Z)-N-(2-(DiethylaMino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide Sunitinib (Mixture of E and Z IsoMer) Sunitinib N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide Sunitinib, >=99% sunitinib SUNITINIB-D4 n-(2-(diethylamino)ethyl)-5-((z)-(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- SUNITINIBMALEATE(FORR&DONLY) Sunitinib--- free base Sunitinib，Sutent 5-(5-Fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid N-(2-diethylaminoethyl)amide Suniti N-[2-(diethylaMino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]Methyl}-2,4-diMethyl-1H-pyrrole-3-carboxaMide SUTENT SUNITINIB N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)meth yl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Sunitinib malate(TINIBS) Sunitinib malate for research N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Maleate SUNITINIB (SU 11248) SU-11248;SU11248 Sunitinib (Sutent, SU11248) SNTI (Z)-N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-2-oxo-3-indolinylidene)methyl]-2,4-dimethylpyrrole-3-carboxamide (Z)-Sunitinib Sunitinib USP/EP/BP Sunitinib DISCONTINUED Sunitinib free base (SU-11248) SunitinibQ: What is Sunitinib Q: What is the CAS Number of Sunitinib Q: What is the storage condition of Sunitinib Q: What are the applications of Sunitinib SUNITINIB MALEATE SUNITINIB BASE Sutent, Sunitinib, SU11248 Sutini 557795-19-4 41031-54-7 C22H27FN4O2C4H6O5 C26H33FN4O7 C26H31FN4O6 C22H27N4O2C4H6O5 26H31FN4O6 SU-11248 Inhibitors anti-neoplastic Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sunitinib Molecular Targeted Antineoplastic Heterocyclic Compounds Pharmaceutical intermediate API Tyrosine Kinase Inhibitors