Teniposide | 29767-20-2

Teniposide Properties

Melting point	244-247°C
Boiling point	650.86°C (rough estimate)
alpha	D20 -107° (9:1 chloroform/methanol)
Density	1.2568 (rough estimate)
refractive index	1.5530 (estimate)
storage temp.	-20°C
solubility	DMSO: soluble10mg/mL, clear
pka	10.13(at 25℃)
form	powder
color	white to beige
optical activity	[α]/D -100 to -115°, c = 1 in chloroform/methanol (9:1)
λmax	283nm(MeOH)(lit.)
Merck	14,9145
Stability	Hygroscopic
CAS DataBase Reference	29767-20-2(CAS DataBase Reference)
IARC	2A (Vol. 76) 2000

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Warning

Hazard statements

H341-H412

Precautionary statements

P202-P273-P280-P308+P313-P405-P501

Hazard Codes

Xi,T

Risk Statements

36/37/38-45

Safety Statements

26-36-45-53

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

3

RTECS

KC0180000

HS Code

29349990

Toxicity

LD50 intraperitoneal in mouse: 29570ug/kg

NFPA 704

	0
2		0

Teniposide price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0609	Teniposide ≥97% (HPLC)	29767-20-2	10MG	₹7653.28	2022-06-14	Buy
Sigma-Aldrich(India)	SML0609	Teniposide ≥97% (HPLC)	29767-20-2	50MG	₹30645.58	2022-06-14	Buy
TCI Chemicals (India)	T3109	Teniposide	29767-20-2	20MG	₹3400	2022-05-26	Buy
TCI Chemicals (India)	T3109	Teniposide	29767-20-2	100MG	₹12700	2022-05-26	Buy

Product number	Packaging	Price	Buy
SML0609	10MG	₹7653.28	Buy
SML0609	50MG	₹30645.58	Buy
T3109	20MG	₹3400	Buy
T3109	100MG	₹12700	Buy

Teniposide Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Teniposide is a podophyllotoxin derivative that causes dose-dependent single- and double-stranded breaks in DNA by inhibiting topoisomerase II. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis. Teniposide has been widely used in the treatment of various cancers including, small cell lung cancer, malignant lymphoma, breast cancer, oral squamous cell carcinoma, and acute lymphoblastic leukemia.

Indications

Teniposide (VM-26, Vumon) is closely related to etoposide in structure, mechanisms of action and resistance, and adverse effects. It is more lipophilic and approximately threefold more potent than etoposide. Its major uses have been in pediatric cancers, particularly in acute lymphoblastic leukemias.

Definition

ChEBI: A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.

General Description

Teniposide is available in 50-mg ampules with Cremophor ELfor IV administration in the treatment of acute lymphoblasticleukemia (ALL). The agent is more potent as an inhibitor oftopoisomerase II. The pharmacokinetics of teniposide issimilar to that of etoposide; however, the more lipophilic teniposideis more highly protein bound (99%) and less isexcreted unchanged in the urine (10%–20%). There is alsogreater overall metabolism of teniposide; however, CYP3A4-mediated conversion to the active catechol is slower comparedwith etoposide. Elimination occurs primarily in the urine witha terminal elimination half-life of 5 hours.

Clinical Use

Teniposide is used in combination with other agents for the treatment of refractory childhood acute lymphoblastic leukemia.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion and intravenous route: anorexia, nausea or vomiting, leukopenia, agranulocytosis and aplastic anemia of the blood, bone marrow changes, and hair changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx.

Teniposide Preparation Products And Raw materials

Raw materials

4'-demethylepipodophyllotoxin-9 beta-glucopyranoside 2-Thiophenecarboxaldehyde

Preparation Products

Teniposide Suppliers

Global( 219)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58	Inquiry
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	China	6387	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49392	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

Teniposide Spectrum

Teniposide(29767-20-2)¹HNMR

29767-20-2(Teniposide)Related Search:

Podophyllotoxin CHLOROPHOSPHONAZO III Centchroman Ethylparaben Methylparaben

Ethyl 4-hydroxybenzoate,sodium salt Sodium methylparaben 4'-demethylepipodophyllotoxin-9 beta-glucopyranoside MATAIRESINOL 3,3-Diphenylpropionic acid

3,5-DIMETHOXYPHENYLPROPIONIC ACID 4'-Demethylepipodophyllotoxin 7-HYDROXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID 2-NAPHTHALENECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-6-HYDROXY- 6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID

3,3-Diphenylpropionic Acid Ethyl Ester (R)-4-(4-Methoxybenzyloxy)-1,2-butanediol (-)-HYDROXYMATAIRESINOL

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(5R,5aα)-5α,8,8aβ,9β-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4-O,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one 4'-Demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene β-D-glucopyranoside) 4’-Demethylepipodophyllotoxin9-(4,6-o-2-thenylidene- 4'-Demethylepipodophyllotoxin thenylidene glucoside Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-o-2-thienylidene-.beta.-D-glucopyranoside) Furo[3',4':6,7]naphtho[2,3-D]-1,3-dioxol-6(5ah)-one, 5,8,8A,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-o-(2-thienylmethylene)-.beta.-D-glucopyranosyl]oxy]-, [5R-(5.alpha.,5A.beta.,8A.alpha.,9.beta.)]- (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-diMethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1,3(7),8-trien-12-one Teniposide(VuMon) (10R,11R,15R,16R)-16-{[(4aR,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-diMethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one (5R,5aR,8aR,9S)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one 4′-Dimethyl-9-(4,6-O-2-thenyid)-epipodophyllotoxin Tenoposide Eniposide 4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-beta-d-glucopyranoside) 4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucosid 4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucoside 4’-demethylepipodophyllotoxin-beta-d-thenylidineglucoside 5abeta,8aalpha,9beta(r*)]]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-[5r-[5alph dimethoxyphenyl)-9]]4-6-o-(2-thienylmethylene)-beta-d-glucopyranosyl]oxy]furo[ epipodophyllotoxin,4’-demethyl-,9-(4,6-o-2-thenylidene-beta-d-glucopyranoside 3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one 4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophyllot 4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophylloto 4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-bata-d-glucopyranoside. nsc122819 nsc-122819 TENIPOSIDE vehem vm-26 Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-b-D-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)- [5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one 4'-Demethyl 1-O-(4,6-O,O-(2-thenylidene)-beta-D-glucopyranosyl)epipodophyllotoxin Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)-oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*))) Pipodophyllotoxin VM 26 Vumon 4'-Dimethylepipodophyllotoxin-9-(4,6-O-2-thenylidene)-b-D-glucopyranoside eniposide, Vumon, VM-26 Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)- Teniposide USP/EP/BP Teniposide Impurity 2 Teniposide (1643736) Methylguanidoacetic acid monohydrate etp (5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-(thiophen-2-yl)hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one Teniposid Teniposide (200 mg) (PLANNED TO BE DISCONTINUED) (5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-(thiophen-2-yl)hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one 4'-Dimethylepipodophyllotoxin-(4,6-O-2-thenylidene)-beta-D-glucopyranoside 29767-20-2 29707-20-2 29767-20-7 C32H32O13S C32H29D3O13S Carbohydrates & Derivatives Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals